GIT2 Antibody

中文名稱：

GIT2兔多克隆抗體
貨號：

CSB-PA613489LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA613489LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA613489LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GIT2 Polyclonal antibody
Uniprot No.：

Q14161
基因名：

GIT2
別名：

ARF GAP GIT2 antibody; ARF GTPase activating protein GIT2 antibody; ARF GTPase-activating protein GIT2 antibody; CAT 2 antibody; CAT-2 antibody; CAT2 antibody; Cool associated tyrosine phosphorylated protein 2 antibody; Cool interacting tyrosine phosphorylated protein 2 antibody; Cool-interacting tyrosine-phosphorylated protein 2 antibody; DKFZp686G01261 antibody; G protein coupled receptor kinase interacting ArfGAP 2 antibody; G protein coupled receptor kinase interactor 2 antibody; G protein-coupled receptor kinase-interactor 2 antibody; GIT 2 antibody; GIT2 antibody; GIT2_HUMAN antibody; GRK interacting protein 2 antibody; GRK-interacting protein 2 antibody; KIAA0148 antibody; MGC760 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human ARF GTPase-activating protein GIT2 protein (1-603AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GIT2 Antibody (CSB-PA613489LA01HU)，的標記方式是Non-conjugated。對于GIT2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA613489LB01HU	GIT2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA613489LC01HU	GIT2 Antibody, FITC conjugated
Biotin	CSB-PA613489LD01HU	GIT2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

GTPase-activating protein for ADP ribosylation factor family members, including ARF1.
基因功能參考文獻：
1. our work identifies DOCK5 as a key regulator of epithelial invasion and metastasis, and demonstrates that suppression of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac GTPases. PMID: 27669437
2. Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35. PMID: 27238570
3. GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses. PMID: 25605334
4. ADMA and L-arginine are substrates of human CAT2A, CAT2B, OCT2 and MATE1. Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine PMID: 23864433
5. Zeb1 is regulated by the Arf GTPase-activating protein (GAP) Git2. PMID: 23591815
6. GIT2 protein is tightly associated with PIX family Rac1/Cdc42 guanine nucleotide exchange factors as a multimeric nexus capable of linking together important signaling molecules. PMID: 15212761
7. The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients. PMID: 16501306
8. GTI proteins regulate cytoskeletal dynamics by feedback inhibition of Rac1, they participate in receptor internalization by regulating membrane trafficking between PMID: 16598076
9. These results suggest that inactivation of GIT2 function is a required step for induction of cell motility and that GIT2 may be a target of oncogenic signaling pathways that regulate cell migration. PMID: 16628223
10. Git2-short, weakly interacting with paxillin, functions in the regulation of Golgi organization, actin cytoskeletal organization, and subcellular localization of paxillin, important in integrin-mediated cell adhesion and intracellular signaling. PMID: 11251077
顯示更多

收起更多
數據庫鏈接：

HGNC: 4273

OMIM: 608564

KEGG: hsa:9815

STRING: 9606.ENSP00000347464

UniGene: Hs.434996

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human