GIT2 Antibody

說明書

中文名稱：

GIT2兔多克隆抗體
貨號：

CSB-PA002690
規格：

￥1090
圖片：
Western Blot analysis of HepG2 cells using GIT2 Polyclonal Antibody

Western Blot analysis of MCF7 cells using GIT2 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q14161
基因名：

GIT2
別名：

ARF GAP GIT2 antibody; ARF GTPase activating protein GIT2 antibody; ARF GTPase-activating protein GIT2 antibody; CAT 2 antibody; CAT-2 antibody; CAT2 antibody; Cool associated tyrosine phosphorylated protein 2 antibody; Cool interacting tyrosine phosphorylated protein 2 antibody; Cool-interacting tyrosine-phosphorylated protein 2 antibody; DKFZp686G01261 antibody; G protein coupled receptor kinase interacting ArfGAP 2 antibody; G protein coupled receptor kinase interactor 2 antibody; G protein-coupled receptor kinase-interactor 2 antibody; GIT 2 antibody; GIT2 antibody; GIT2_HUMAN antibody; GRK interacting protein 2 antibody; GRK-interacting protein 2 antibody; KIAA0148 antibody; MGC760 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human GIT2.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

GTPase-activating protein for ADP ribosylation factor family members, including ARF1.
基因功能參考文獻：
1. our work identifies DOCK5 as a key regulator of epithelial invasion and metastasis, and demonstrates that suppression of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac GTPases. PMID: 27669437
2. Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35. PMID: 27238570
3. GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses. PMID: 25605334
4. ADMA and L-arginine are substrates of human CAT2A, CAT2B, OCT2 and MATE1. Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine PMID: 23864433
5. Zeb1 is regulated by the Arf GTPase-activating protein (GAP) Git2. PMID: 23591815
6. GIT2 protein is tightly associated with PIX family Rac1/Cdc42 guanine nucleotide exchange factors as a multimeric nexus capable of linking together important signaling molecules. PMID: 15212761
7. The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients. PMID: 16501306
8. GTI proteins regulate cytoskeletal dynamics by feedback inhibition of Rac1, they participate in receptor internalization by regulating membrane trafficking between PMID: 16598076
9. These results suggest that inactivation of GIT2 function is a required step for induction of cell motility and that GIT2 may be a target of oncogenic signaling pathways that regulate cell migration. PMID: 16628223
10. Git2-short, weakly interacting with paxillin, functions in the regulation of Golgi organization, actin cytoskeletal organization, and subcellular localization of paxillin, important in integrin-mediated cell adhesion and intracellular signaling. PMID: 11251077
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數據庫鏈接：

HGNC: 4273

OMIM: 608564

KEGG: hsa:9815

STRING: 9606.ENSP00000347464

UniGene: Hs.434996

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