GFRA4 Antibody

說(shuō)明書

中文名稱：

GFRA4兔多克隆抗體
貨號(hào)：

CSB-PA271998
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA271998(GFRA4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA271998(GFRA4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產(chǎn)品詳情

Uniprot No.：

Q9GZZ7
基因名：

GFRA4
別名：

GDNF family receptor alpha 4 antibody; GDNF family receptor alpha-4 antibody; GDNF receptor alpha-4 antibody; GDNFR-alpha-4 antibody; GFR alpha 4 antibody; GFR receptor alpha 4 antibody; GFR-alpha-4 antibody; GFRA4 antibody; GFRA4_HUMAN antibody; Glial cell line derived neurotrophic factor family receptor alpha 4 antibody; Neurotrophic factor receptor splice variant A (Gfra4 gene) antibody; OTTHUMP00000030106 antibody; OTTHUMP00000030107 antibody; Persephin receptor antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthetic peptide of Human GFRA4
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
基因功能參考文獻(xiàn)：
1. Results support that aberrant CpG hypermethylation at least partly accounts for GFRA4 silencing in HSCR, which impairs its protective role in enteric nervous system. PMID: 29634418
2. High GFRA4 expression is associated with Hirschsprung's Disease. PMID: 29090971
3. GDNF/GFRalpha1 is crucial for efficient signal transduction to recruit Ret protein into lipid rafts. PMID: 15225646
亞細(xì)胞定位：

[Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted.
蛋白家族：

GDNFR family
組織特異性：

Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 13821

KEGG: hsa:64096

STRING: 9606.ENSP00000313423

UniGene: Hs.302025

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