GFRA4 Antibody

說明書

產品詳情

Uniprot No.：

Q9GZZ7
基因名：

GFRA4
別名：

GDNF family receptor alpha 4 antibody; GDNF family receptor alpha-4 antibody; GDNF receptor alpha-4 antibody; GDNFR-alpha-4 antibody; GFR alpha 4 antibody; GFR receptor alpha 4 antibody; GFR-alpha-4 antibody; GFRA4 antibody; GFRA4_HUMAN antibody; Glial cell line derived neurotrophic factor family receptor alpha 4 antibody; Neurotrophic factor receptor splice variant A (Gfra4 gene) antibody; OTTHUMP00000030106 antibody; OTTHUMP00000030107 antibody; Persephin receptor antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human GFRα-4.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
基因功能參考文獻：
1. Results support that aberrant CpG hypermethylation at least partly accounts for GFRA4 silencing in HSCR, which impairs its protective role in enteric nervous system. PMID: 29634418
2. High GFRA4 expression is associated with Hirschsprung's Disease. PMID: 29090971
3. GDNF/GFRalpha1 is crucial for efficient signal transduction to recruit Ret protein into lipid rafts. PMID: 15225646
亞細胞定位：

[Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted.
蛋白家族：

GDNFR family
組織特異性：

Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
數據庫鏈接：

HGNC: 13821

KEGG: hsa:64096

STRING: 9606.ENSP00000313423

UniGene: Hs.302025

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