GFRA2 Antibody

說(shuō)明書

中文名稱：

GFRA2兔多克隆抗體
貨號(hào)：

CSB-PA009380LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate, Mouse liver tissue, Mouse lung tissue, Mouse kidney tissue, Mouse brain tissue
All lanes: GFRA2 antibody at 3.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 37, 40 kDa
Observed band size: 34 kDa

Immunofluorescent analysis of HepG2 cells using CSB-PA009380LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GFRA2 Polyclonal antibody
Uniprot No.：

O00451
基因名：

GFRA2
別名：

GDNF family receptor alpha 2 antibody; GDNF family receptor alpha-2 antibody; GDNF receptor alpha-2 antibody; GDNF receptor beta antibody; GDNFR beta antibody; GDNFR-alpha-2 antibody; GDNFR-beta antibody; GDNFRB antibody; GFR alpha 2 antibody; GFR-alpha-2 antibody; GFRA 2 antibody; Gfra2 antibody; GFRA2_HUMAN antibody; Glial cell line derived neurotrophic factor family receptor alpha2b antibody; Glial cell line derived neurotrophic factor receptor beta antibody; Neurturin receptor alpha antibody; NRTNR alpha antibody; NRTNR-alpha antibody; NTNR alpha antibody; NTNR-alpha antibody; NTNRA antibody; PI linked cell surface accessory protein antibody; PI linked cell-surface accessory protein antibody; RET ligand 2 antibody; RETL 2 antibody; RETL2 antibody; TGF beta related neurotrophic factor receptor 2 antibody; TGF-beta-related neurotrophic factor receptor 2 antibody; TRN receptor GPI anchored antibody; TRNR 2 antibody; TRNR2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human GDNF family receptor alpha-2 protein (242-415AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，GFRA2 Antibody (CSB-PA009380LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于GFRA2 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA009380LB01HU	GFRA2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA009380LC01HU	GFRA2 Antibody, FITC conjugated
Biotin	CSB-PA009380LD01HU	GFRA2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.; participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
基因功能參考文獻(xiàn)：
1. biophysical results show that the relative concentration of GFRa2 on cell surfaces can affect the functional affinity of NRTN through avidity effects. PMID: 29414779
2. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase. PMID: 27396331
3. High GFRalpha2 expression level leads to PTEN inactivation via Mir-17-5p up-regulation, promoting pancreatic tumor cell growth and chemoresistance. PMID: 27400681
4. GFRA2 variants associated with diabetic neuropathic pain. PMID: 24974787
5. GFRalpha2 is under-expressed in functioning adenomas and over-expressed in non-functioning adenomas, specifically gonadotropinomas PMID: 24402129
6. In the cochlea, immunolabeling for GFRalpha-2 receptors was identified mainly in the cell bodies of the spiral neurons than in the nerve fibers. No structures in the organ of Corti were labeled with GFRalpha-2 receptor antibody PMID: 24139947
7. GFRalpha-2 is associated with severe abdominal pain sensation in pancreatic cancer patients. PMID: 24067900
8. Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms. PMID: 21723942
9. GFRA2 genetic variants, and age, may play a role in susceptibility to tardive dyskinesia. PMID: 20369355
10. Both GFR alpha2a and GFR alpha2c, but not GFR alpha2b, promote neurite outgrowth in transfected Neuro2A cells. PMID: 17522305
11. GFRalpha-2 were observed within sensory and motor nuclei of cranial nerves, dorsal column nuclei, olivary nuclear complex, reticular formation, pontine nuclei, locus caeruleus, raphe nuclei, substantia nigra, and quadrigeminal plate. PMID: 17825269
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亞細(xì)胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

GDNFR family
組織特異性：

Isoform 1 is found in both brain and placenta.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 4244

OMIM: 601956

KEGG: hsa:2675

STRING: 9606.ENSP00000428518

UniGene: Hs.441202

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