GFRA2 Antibody

說明書

中文名稱：

GFRA2兔多克隆抗體
貨號：

CSB-PA135383
規格：

￥1100
圖片：
Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: Human liver cancer tissue, Primary antibody: CSB-PA135383(GFRA2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
其他：

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靶點詳情

產品詳情

Uniprot No.：

O00451
基因名：

GFRA2
別名：

GDNF family receptor alpha 2 antibody; GDNF family receptor alpha-2 antibody; GDNF receptor alpha-2 antibody; GDNF receptor beta antibody; GDNFR beta antibody; GDNFR-alpha-2 antibody; GDNFR-beta antibody; GDNFRB antibody; GFR alpha 2 antibody; GFR-alpha-2 antibody; GFRA 2 antibody; Gfra2 antibody; GFRA2_HUMAN antibody; Glial cell line derived neurotrophic factor family receptor alpha2b antibody; Glial cell line derived neurotrophic factor receptor beta antibody; Neurturin receptor alpha antibody; NRTNR alpha antibody; NRTNR-alpha antibody; NTNR alpha antibody; NTNR-alpha antibody; NTNRA antibody; PI linked cell surface accessory protein antibody; PI linked cell-surface accessory protein antibody; RET ligand 2 antibody; RETL 2 antibody; RETL2 antibody; TGF beta related neurotrophic factor receptor 2 antibody; TGF-beta-related neurotrophic factor receptor 2 antibody; TRN receptor GPI anchored antibody; TRNR 2 antibody; TRNR2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human GFRA2
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:5000
WB	1:200-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.; participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
基因功能參考文獻：
1. biophysical results show that the relative concentration of GFRa2 on cell surfaces can affect the functional affinity of NRTN through avidity effects. PMID: 29414779
2. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase. PMID: 27396331
3. High GFRalpha2 expression level leads to PTEN inactivation via Mir-17-5p up-regulation, promoting pancreatic tumor cell growth and chemoresistance. PMID: 27400681
4. GFRA2 variants associated with diabetic neuropathic pain. PMID: 24974787
5. GFRalpha2 is under-expressed in functioning adenomas and over-expressed in non-functioning adenomas, specifically gonadotropinomas PMID: 24402129
6. In the cochlea, immunolabeling for GFRalpha-2 receptors was identified mainly in the cell bodies of the spiral neurons than in the nerve fibers. No structures in the organ of Corti were labeled with GFRalpha-2 receptor antibody PMID: 24139947
7. GFRalpha-2 is associated with severe abdominal pain sensation in pancreatic cancer patients. PMID: 24067900
8. Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms. PMID: 21723942
9. GFRA2 genetic variants, and age, may play a role in susceptibility to tardive dyskinesia. PMID: 20369355
10. Both GFR alpha2a and GFR alpha2c, but not GFR alpha2b, promote neurite outgrowth in transfected Neuro2A cells. PMID: 17522305
11. GFRalpha-2 were observed within sensory and motor nuclei of cranial nerves, dorsal column nuclei, olivary nuclear complex, reticular formation, pontine nuclei, locus caeruleus, raphe nuclei, substantia nigra, and quadrigeminal plate. PMID: 17825269
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

GDNFR family
組織特異性：

Isoform 1 is found in both brain and placenta.
數據庫鏈接：

HGNC: 4244

OMIM: 601956

KEGG: hsa:2675

STRING: 9606.ENSP00000428518

UniGene: Hs.441202

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