GDF10 Antibody

文獻引用 (1) 說明書

產品詳情

產品描述：

The rabbit anti-human GDF10 polyclonal antibody is an IgG antibody produced in rabbits that specifically recognizes and binds to the human and rat GDF10 protein. Its immunogen is the recombinant human GDF10 protein (369-478aa). Protein G purification of this GDF10 antibody brought it a purity of up to 95%. The specificity and reliability of this GDF10 antibody have been verified in ELISA, WB, and IHC applications.

GDF10 plays a crucial role in the regulation of cell growth, differentiation, and development in various tissues and organs. It especially promotes cell differentiation in the skeletal and nervous systems. It is also involved in the development and maintenance of bone and cartilage, as well as in the formation and repair of neural tissue.
產品名稱：

Rabbit anti-Homo sapiens (Human) GDF10 Polyclonal antibody
Uniprot No.：

P55107
基因名：

GDF10
別名：

BIP antibody; BMP 3b antibody; BMP-3b antibody; BMP3B antibody; BMP3B_HUMAN antibody; Bone inducing protein antibody; Bone morphogenetic protein 3b [Precursor] antibody; Bone morphogenetic protein 3b antibody; Bone-inducing protein antibody; GDF 10 antibody; GDF-10 antibody; Gdf10 antibody; growth differentiation factor 10 antibody; Growth/differentiation factor 10 antibody
宿主：

Rabbit
反應種屬：

Human, Rat
免疫原：

Recombinant Human Growth/differentiation factor 10 protein (369-478AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GDF10 Antibody (CSB-PA009343LA01HU)，的標記方式是Non-conjugated。對于GDF10 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA009343LB01HU	GDF10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA009343LC01HU	GDF10 Antibody, FITC conjugated
Biotin	CSB-PA009343LD01HU	GDF10 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
基因功能參考文獻：
1. Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 which shares the signaling inhibiting epithelial-mesenchymal transition. PMID: 25728212
2. GDF10 is a stroke-induced signal for axonal sprouting and functional recovery. PMID: 26502261
3. new hypoxia-inducible and SOX9-regulated genes, Gdf10 and Chm-I. In addition, Mig6 and InhbA were induced by hypoxia, predominantly via HIF-2alpha PMID: 18077449
4. BMP3b and BMP6 genes were suppressed by DNA methylation and methylation of BMP3b is significantly frequent in Japanese malignant pleural mesotheliomas (MPMs), suggesting its pathogenic role and the ethnic difference in MPMs. PMID: 18949431
亞細胞定位：

Secreted.
蛋白家族：

TGF-beta family
組織特異性：

Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
數據庫鏈接：

HGNC: 4215

OMIM: 601361

KEGG: hsa:2662

STRING: 9606.ENSP00000224605

UniGene: Hs.2171

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