GDF1 Antibody

說明書

中文名稱：

GDF1兔多克隆抗體
貨號：

CSB-PA159987
規(guī)格：

￥1100
圖片：
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA159987(GDF1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P27539
基因名：

GDF1
別名：

DORV antibody; DTGA3 antibody; Embryonic growth/differentiation factor 1 antibody; GDF 1 antibody; GDF-1 antibody; GDF1 antibody; GDF1_HUMAN antibody; Growth differentiation factor 1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human GDF1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

May mediate cell differentiation events during embryonic development.
基因功能參考文獻：
1. Our results suggest that the GDF1 rs4808863 polymorphism contributes to an increased risk of fetal CHDs, especially the subtypes of AVSD, LVOTO and left-right laterality defects. PMID: 26656983
2. This implies that Gdf1 potentiates Nodal activity by stabilizing a low molecular weight fraction that is susceptible to neutralization by soluble Acvr2. PMID: 24798330
3. indicate that the expression of growth/differentiation factor 1 (GDF1) is up-regulated in human dilated cardiomyopathy (DCM)hearts and murine hypertrophic hearts. PMID: 24275554
4. GDF1 may be associated with congenital heart defects risk, and these variations contribute at least in part to the development of some subtypes of conotruncal defects in the Chinese Han population. PMID: 23076529
5. Molecular genetic basis of a kindred with 5 siblings with right atrial isomerism involved mutations in GDF1. PMID: 20413652
6. Heterozygous loss-of-function mutations in the human GDF1 gene contribute to cardiac defects ranging from tetralogy of Fallot to transposition of the great arteries. PMID: 17924340
7. GDF1 expression is correlated with progression and aggressive behaviors in cervical cancer, suggesting a tumor-promoting role for GDF1 in the progression of this malignancy. PMID: 19359031
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相關(guān)疾病：

Conotruncal heart malformations (CTHM); Transposition of the great arteries dextro-looped 3 (DTGA3); Tetralogy of Fallot (TOF); Right atrial isomerism (RAI)
亞細胞定位：

Secreted.
蛋白家族：

TGF-beta family
組織特異性：

Expressed in the brain.
數(shù)據(jù)庫鏈接：

HGNC: 4214

OMIM: 187500

KEGG: hsa:2657

STRING: 9606.ENSP00000247005

UniGene: Hs.412355

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