FDXR Antibody

中文名稱：

FDXR兔多克隆抗體
貨號：

CSB-PA008575LA01HU
規格：

￥440
圖片：
Western blot
All lanes: FDXR antibody at 6µg/ml
Lane 1: A549 whole cell lysate
Lane 2: Mouse liver tissue
Lane 3: HepG2 whole cell lysate
Lane 4: U251 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54, 55, 59, 49, 53, 50, 58 kDa
Observed band size: 54 kDa

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA008575LA01HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FDXR Polyclonal antibody
Uniprot No.：

P22570
基因名：

FDXR
別名：

Adrenodoxin reductase antibody; ADRO_HUMAN antibody; ADXR antibody; AR antibody; FDXR antibody; Ferredoxin NADP(+) reductase antibody; Ferredoxin reductase antibody; Ferredoxin--NADP(+) reductase antibody; mitochondrial antibody; NADPH adrenodoxin oxidoreductase mitochondrial antibody; NADPH:adrenodoxin oxidoreductase antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human NADPH:adrenodoxin oxidoreductase, mitochondrial protein (33-451AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，FDXR Antibody (CSB-PA008575LA01HU)，的標記方式是Non-conjugated。對于FDXR Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA008575LB01HU	FDXR Antibody, HRP conjugated	ELISA
FITC	CSB-PA008575LC01HU	FDXR Antibody, FITC conjugated
Biotin	CSB-PA008575LD01HU	FDXR Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
基因功能參考文獻：
1. These data provide further insight into the pathogenic mechanism of FDXR-mediated central neuropathy, and suggest an avenue for mechanistic studies that will ultimately inform treatment. PMID: 30250212
2. we identified a novel disease-causing gene FDXR associated with mitochondrial diseases. The biallelic FDXR mutations cause optic atrophy and neuropathy. we found that FDXR levels are significantly lower in the patient fibroblast cells with the homozygous mutations R392W. Fourteen missense or nonsense FDXR mutations were identified in this study and eight of them (I143F, V158M, T211A, I213F, K280*, R315*, C359Y, D374N) clu PMID: 29040572
3. Using surface plasmon resonance, physiologically relevant concentrations of isatin (25-100 muM) were found to increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR). PMID: 28905435
4. Mutation in FDXR gene is associated with Sensorial Neuropathies. PMID: 28965846
5. NOS-3 overexpression resulted in an increased sensitivity to anti-Fas induced cell death, independently of AR expression and CatD activity. PMID: 25712867
6. These results indicated that abundant FDXR expression in these steroidogenic cells was maintained through SF-1 binding to the intronic enhancer of the FDXR gene PMID: 24321386
7. results suggest that both FDX1 and FDX2 and their likely reductase partner, FDXR, contribute to iron-sulfur cluster biogenesis PMID: 22101253
8. comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase [cytochrome P450scc] PMID: 12137805
9. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis PMID: 12370809
10. ADXR rate of hydroxylation was linear with incubation time. PMID: 12782149
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亞細胞定位：

Mitochondrion inner membrane; Peripheral membrane protein.
蛋白家族：

Ferredoxin--NADP reductase type 1 family
數據庫鏈接：

HGNC: 3642

OMIM: 103270

KEGG: hsa:2232

STRING: 9606.ENSP00000462972

UniGene: Hs.69745

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