FASTKD2 Antibody

中文名稱：

FASTKD2兔多克隆抗體
貨號：

CSB-PA882149LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Rat heart tisseu, Mouse heart tissue
All lanes: FASTKD2 antibody at 8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 82, 75 kDa
Observed band size: 75 kDa

IHC image of CSB-PA882149LA01HU diluted at 1:300 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA882149LA01HU diluted at 1:300 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FASTKD2 Polyclonal antibody
Uniprot No.：

Q9NYY8
基因名：

FASTKD2
別名：

FAKD2_HUMAN antibody; FAST kinase domain containing protein 2 antibody; FAST kinase domain-containing protein 2 antibody; FAST kinase domains 2 antibody; Fastkd2 antibody; KIAA0971 antibody
宿主：

Rabbit
反應種屬：

Human, Rat, Mouse
免疫原：

Recombinant Human FAST kinase domain-containing protein 2, mitochondrial protein (117-203AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，FASTKD2 Antibody (CSB-PA882149LA01HU)，的標記方式是Non-conjugated。對于FASTKD2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA882149LB01HU	FASTKD2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA882149LC01HU	FASTKD2 Antibody, FITC conjugated
Biotin	CSB-PA882149LD01HU	FASTKD2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:100-1:300

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. May play a role in mitochondrial apoptosis.
基因功能參考文獻：
1. Despite the fact that proteins of the FASTK family FASTKD1-5 share the same domains, they exhibit various-sometimes opposing-functions in almost all steps of mitochondrial RNA metabolism. PMID: 29036396
2. Authors discovered a novel association of a polymorphism in the pro-apoptotic gene FASTKD2 (fas-activated serine/threonine kinase domains 2) with better memory performance PMID: 25385369
3. CRISPR-mediated deletion of FASTKD2 leads to aberrant processing. PMID: 26370583
4. Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain. PMID: 25409762
5. regulation of FASTKD2 by NRIF3 and the DIF-1 complex acts as a novel death switch that selectively modulates apoptosis in breast cancer PMID: 21444724
6. mutation in a gene segregating with a peculiar mitochondrial encephalomyopathy associated with COX deficiency in skeletal muscle. FASTKD2 is localized in the mitochondrial inner compartment. PMID: 18771761
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亞細胞定位：

Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion matrix.
蛋白家族：

FAST kinase family
組織特異性：

Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle and thyroid.
數據庫鏈接：

HGNC: 29160

OMIM: 612322

KEGG: hsa:22868

STRING: 9606.ENSP00000236980

UniGene: Hs.5930

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