FANCB Antibody

中文名稱：

FANCB兔多克隆抗體
貨號：

CSB-PA818751LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of PC-3 cells with CSB-PA818751LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FANCB Polyclonal antibody
Uniprot No.：

Q8NB91
基因名：

FANCB
別名：

FA2 antibody; FAAP90 antibody; FAAP95 antibody; FAB antibody; FACB antibody; Fancb antibody; FANCB_HUMAN antibody; Fanconi anemia associated polypeptide of 95 kDa antibody; Fanconi anemia group B protein antibody; Fanconi anemia; complementation group B antibody; Fanconi anemia-associated polypeptide of 95 kDa antibody; Protein FACB antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Fanconi anemia group B protein (431-574AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，FANCB Antibody (CSB-PA818751LA01HU)，的標記方式是Non-conjugated。對于FANCB Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA818751LB01HU	FANCB Antibody, HRP conjugated	ELISA
FITC	CSB-PA818751LC01HU	FANCB Antibody, FITC conjugated
Biotin	CSB-PA818751LD01HU	FANCB Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

DNA repair protein required for FANCD2 ubiquitination.
基因功能參考文獻：
1. We identified a 9154 bp intragenic duplication in FANCB, covering the first coding exon 3 and the flanking regions. The duplicated allele gives rise to an aberrant transcript containing exon 3 duplication, predicted to introduce a stop codon in FANCB protein (p.A319*). PMID: 29193904
2. Four single nucleotide polymorphisms were identified, three of which were located in untranslated regions of Fanconi anemia group B protein (FANCB) and predicted to be associated with normal function. PMID: 29491055
3. Loss-of-function FANCB mutations result in a recognizable, multiple malformation phenotype in hemizygous males for which we propose clinical criteria to aid diagnosis. PMID: 21910217
4. Inactivation of FancB may play a role in the pathogenesis of sporadic HNSCC. PMID: 20332657
5. Elevated serum FA-2 was associated with bony metastases from breast cancer. PMID: 20465790
6. the protein defective in individuals with Fanconi anemia belonging to complementation group B is an essential component of the nuclear protein 'core complex' responsible for monoubiquitination of FANCD2 PMID: 15502827
7. summary of recent advances in the Fanconi anemia-BRCA network with emphasis on the new discovery of FAAP95 as the true FANCB gene [review] PMID: 15611632
8. Mutations in FANCB are a cause of X linked VACTERL-H syndrome. PMID: 16679491
9. Mus81 and FANCB have different roles in repair of DNA damage during replication in human cells PMID: 17903171
10. Our results rule out a major contribution of FANCB to hereditary breast cancer. PMID: 18302019
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相關疾病：

Fanconi anemia complementation group B (FANCB)
亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 3583

OMIM: 300514

KEGG: hsa:2187

STRING: 9606.ENSP00000326819

UniGene: Hs.554740

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