ERP44 Antibody
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中文名稱：ERP44兔多克隆抗體
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貨號：CSB-PA007801GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Endoplasmic reticulum resident protein 44 antibody; Endoplasmic reticulum resident protein 44 kDa antibody; Endoplasmic reticulum resident protein ERp44 antibody; ER protein 44 antibody; ERp44 antibody; ERP44_HUMAN antibody; KIAA0573 antibody; PDIA10 antibody; Protein disulfide isomerase family A; member 10 antibody; Thioredoxin domain containing 4 (endoplasmic reticulum) antibody; Thioredoxin domain containing protein 4 antibody; Thioredoxin domain-containing protein 4 antibody; UNQ532/PRO1075 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human ERP44
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.
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基因功能參考文獻：
- Endogenous ERp44 is O-glycosylated and secreted by human primary endometrial cells, suggesting possible pathophysiological roles of these processes. PMID: 25097228
- findings indicated that overexpression of miR-101 could downregulate ERp44 PMID: 24804790
- the decrease in 5-HT uptake rates of GDM trophoblast is the consequence of defective insulin signaling, which entraps SERT with ERp44 and impairs its glycosylation. PMID: 25512553
- The ERp44 assembly control cycle couples secretion fidelity and efficiency downstream of the calnexin/calreticulin and BiP-dependent quality control cycles. PMID: 23685074
- ERp44 together with Ero1-Lalpha plays an important role in disulfide formation of SERT, which may be a prerequisite step for the assembly of SERT molecules in oligomeric form. PMID: 22451649
- contains a thioredoxin domain with a CRFS motif and is induced during ER stress PMID: 11847130
- Ero1alpha and Ero1beta are retained in the endoplasmic reticulum by interactions with PDI and ERp44 PMID: 16677073
- ERGIC-53 provides a platform that receives micro(2)L(2) subunits from the BiP-dependent checkpoint, assisting polymerization. In this process, ERp44 couples thiol-dependent assembly and quality control. PMID: 17805346
- ERp44-mediated retention of FGE, indicating that noncovalent interactions between ERp44 and FGE are sufficient to mediate ER retention. PMID: 18178549
- Study shows that SUMF1 interacts with protein disulfide isomerase (PDI) and ERp44, two thioredoxin family members residing in the early secretory pathway, and with ERGIC-53, a lectin that shuttles between the ER and the Golgi. PMID: 18508857
- Crystal structure of ERp44 at a resolution of 2.6 A, is presented. PMID: 18552768
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亞細胞定位：Endoplasmic reticulum lumen.
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數據庫鏈接：
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