EPHX2 Antibody, Biotin conjugated
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中文名稱：EPHX2兔多克隆抗體, Biotin偶聯(lián)
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貨號(hào)：CSB-PA007735LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) EPHX2 Polyclonal antibody
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Uniprot No.：
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基因名：EPHX2
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別名：Bifunctional epoxide hydrolase 2 antibody; CEH antibody; Cytosolic epoxide hydrolase antibody; EPHX2 antibody; Epoxide hydratase antibody; Epoxide hydrolase 2 antibody; Epoxide hydrolase 2 cytoplasmic antibody; epoxide hydrolase 2, cytosolic antibody; Epoxide hydrolase soluble antibody; HYES_HUMAN antibody; SEH antibody; Soluble epoxide hydrolase antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Bifunctional epoxide hydrolase 2 protein (1-555AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators.; Bifunctional enzyme. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid. Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates.
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基因功能參考文獻(xiàn)：
- the A allele of exonic polymorphism in EPHX2 rs751141 is negatively associated with the incidence of diabetic nephropathy in the Chinese type 2 diabetes population, which could be modulated by homocysteine level status. PMID: 29629376
- Single nucleotide polymorphism of EPHX2 rs751141 is associated with Early Neurological Deterioration. PMID: 28835580
- The activity of Ephx2 promoter-coding luciferase was significantly attenuated in HEK293T cells treated with 17beta-E2. PMID: 29295935
- hypomethylation of the promoter region of EPHX2 and K55R polymorphism were associated with significant increased risk of pre-eclampsia. PMID: 29058492
- Study demonstrated an isolated gene change, sEH R287Q, in a core family of familial hypercholesterolemia (FH). The results showed that sEH R287Q decreased the expression level and hydrolase activity of sEH, decreased the binding of LDL to LDLR and LDL internalization in cultured hepatocyte cell line BEL-7402. PMID: 29665449
- Soluble epoxide hydrolase plays role in the choroidal neovascularization PMID: 29193961
- Interestingly, rs2279590 locus has a widespread enhancer effect on two nearby genes, protein tyrosine kinase 2 beta (PTK2B) and epoxide hydrolase-2 (EPHX2); both of which have been previously associated with AD as risk factors. PMID: 28973302
- Results showed that among type 2 diabetic patients, the combined effect of MTHFR TT and EPHX2 GG or GA + AA genotype has a higher risk of ischemic stroke compared with the control group. PMID: 28409162
- we describe the bacterial expression of the recombinant N-terminal domain of sEH-P and the development of a high-throughput screening protocol using a sensitive and commercially available substrate fluorescein diphosphate. The usability of the assay system was demonstrated and novel inhibitors of sEH-P were identified. PMID: 27009944
- The WT sEH formed a very tight dimer, with a KD/M in the low picomolar range. Only R287Q resulted in a large change of the KD/M However, human tissue concentrations of sEH suggest that it is always in its dimer form independently of the SNP. PMID: 24771868
- The EPHX2 Lys55Arg polymorphism is associated with AKI following cardiac surgery in patients without preexisting CKD PMID: 28552948
- EPHX2 polymorphism , might be important determinant of hydrochlorothiazide treatment in patients with hypertension. PMID: 27381900
- This study meta-analysis results did not show significant associations between the polymorphisms of EPHX2. PMID: 27266621
- EPHX2 Variants are associated with Ischemic Stroke. PMID: 27087514
- Because Epoxide Hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN. PMID: 25824304
- Increased levels of soluble epoxide hydrolase in the brain of depressed patients PMID: 26976569
- carriers of rs1042032 GG genotype had lower estimated glomerular filtration rate and higher serum creatinine values 1 year after grafting compared to patients carrying wildtype A-allele; this GG genotype also associated to increased risk of acute rejection; results suggest genetic variability in EPHX2 may have an impact on outcome of deceased-donor renal transplantation PMID: 26230946
- Suggest role for Ephx2 in vascular smooth muscle phenotypic modulation and migration in the development of atherosclerosis. PMID: 26453326
- Essential hypertension is associated with the rs751141 G/A allele gene polymorphism in EPHX2 in Han subjects but not in Kazakh and Uygur subjects. PMID: 25966114
- Within the EPHX2 promoter -56/+32, five Sp1-binding sites were identified, and the mutation of each of these sites showed that the first one (SP1_1) was important in both suppression by Sp1 and activation by AP2alpha. PMID: 26341485
- A genetic variant that results in decreased soluble epoxide hydrolase activity is associated with increased insulin sensitivity. PMID: 25173047
- Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo. PMID: 25659109
- Genetic polymorphisms of soluble EH are associated with neurological and vital outcomes after aneurysmal subarachnoid hemorrhage. PMID: 25216066
- Findings suggest a novel association of gene variants within EPHX2 to susceptibility to anorexia nervosa and provide a foundation for future study of this important yet poorly understood condition PMID: 23999524
- Presence of single nucleotide polymorphism rs751141 of EPHX2 is associated with significantly increased risk of atrial fibrillation recurrence following catheter ablation. PMID: 23711456
- Evidence suggests that modulation of plasma levels of epoxyeicosatrienoic acid (EET) (for example, down-regulation of EET in patients with renovascular disease-associated hypertension) is due, in part, to up-regulation of EPHX2. [REVIEW] PMID: 23011468
- sEH is a physiological modulator of ER stress and a potential target for mitigating complications associated with obesity PMID: 23576437
- the importance of sEH in MCP-1-regulated monocyte chemotaxis PMID: 23160182
- Soluble epoxide hydrolase dimerization is required for hydrolase activity PMID: 23362272
- The essential hypertension in Kazaks in Xinjiang is not associated with rs751141G/A gene polymorphism, but is associated with rs751141G/A allele gene polymorphism of EPHX2. PMID: 22336502
- Upregulation of sEH in proximal tubular cells in chronic proteinuric kidney diseases may mediate proteinuria-induced renal damage. PMID: 23152298
- investigation of role of cytoplasmic Ephx2 in diabetic nephropathy by gene disruption techniques: Ephx2 gene inhibition (or added epoxyeicosatrienoic acids) protects renal proximal tubular cell line from tumor necrosis factor-alpha-induced apoptosis. PMID: 22739108
- sEH is one of the etiological factors of cardiovascular diseases, and plays an important role in the progression of myocardium ischemia. PMID: 21704394
- ATF6 activation and DNA demethylation may coordinately contribute to Hcy-induced sEH expression and endothelial activation. PMID: 22354938
- These findings also underline possible cellular mechanisms by which both activities of sEH (EH and phosphatase) may have complementary or opposite roles. PMID: 22387545
- This case-control study as well as meta-analysis suggested no association between CYP2J2 G-50T and EPHX2 R287Q and the risk of developing coronary artery disease . PMID: 21642892
- In patients with IgA nephropathy, some single nucleotide polymorphisms of EPHX2 were associated with more rapid disease progression. PMID: 21429967
- The PLA2G7, HPGD, EPHX2, and CYP4F8 genes are highly expressed in prostate cancer. PMID: 21281786
- SP-1 is involved in the decrease in the transcription of sEH as a result of DNA methylation in HepG2 cells, which might contribute to epigenetic mechanism-induced carcinogenesis in hepatocytes. PMID: 20888937
- Genetic variation in epoxide hydrolase 2 is associated with forearm vasodilator responses in a bradykinin receptor- and endothelium-independent manner, suggesting an important role for soluble epoxide hydrolase in regulating vascular function in humans. PMID: 21098312
- The functional K55R polymorphism of the EPHX2 gene confers a higher risk of hypertension prevalence and increases the risk of incident ischemic stroke in male homozygotes. PMID: 20065888
- Results show that no relationship exists between EPHX2 and risk of ischemic stroke, myocardial infarction, and ischemic heart disease. PMID: 19940276
- Common polymorphisms within EPHX2 do not appear to be important risk factors for Parkinson's disease. PMID: 11692079
- Close association of soluble epoxide hydrolase gene G860A (Arg287Gln) polymorphism with insulin resistance in type 2 diabetic patients. PMID: 15845398
- Multiple variants exist within or near the EPHX2 gene, with greatly contrasting relationships to ischemic stroke incidence; some associated with a higher incidence and others with a lower incidence. PMID: 16115816
- Soluble epoxide epoxygenase-related SNP is not associated with increased risk of hypertension in the African American population. PMID: 16202848
- Consistent with the finding of isoprenoid phosphates as substrates for sEH, we identified isoprenoid-derived N-terminal inhibitors with IC50 values ranging from 0.84 (+/-0.9) to 55.1 (+/-30.7) microM. PMID: 16414022
- EPHX2 has an emerging role as a risk factor for atherosclerosis, whose effects are influenced by smoking PMID: 16545818
- EPHX2 as a potential cardiovascular disease-susceptibility gene. PMID: 16595607
- human EPHX2 mutations may in part explain the genetic variability in sensitivity to ischemic brain injury and stroke outcome PMID: 17460077
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亞細(xì)胞定位：Cytoplasm. Peroxisome.
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蛋白家族：AB hydrolase superfamily, Epoxide hydrolase family
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