EDN3 Antibody
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中文名稱：EDN3兔多克隆抗體
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貨號：CSB-PA007402GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：EDN3
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別名：EDN3 antibody; EDN3_HUMAN antibody; Endothelin 3 antibody; Endothelin-3 antibody; ET 3 antibody; ET-3 antibody; PPET3 antibody; Preproendothelin 3 antibody; Preproendothelin-3 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human EDN3
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Endothelins are endothelium-derived vasoconstrictor peptides.
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基因功能參考文獻：
- the critical physiological role of the KIT-ET3-NO pathway in fulfilling high demand (exceeding basal level) of endothelium-dependent NO generation for coping with atherosclerosis, pregnancy, and aging, is reported. PMID: 28880927
- genome-wide association studies in population of women in China: Data suggest that EDN3 (endothelin 3) and EDNRB (endothelin receptor type B) play important roles in the molecular mechanisms underlying cervical cancer. PMID: 27863272
- EDN3 expression in left internal mammary arteries depends on tissue harvesting technique. PMID: 24647318
- Down-regulated expression of ET3 attenuates the malignant behaviors of human melanoma cells partially by decreasing the expression of SPARC. PMID: 23904381
- Waardenburg syndrome type II and mutations of EDNRB, EDN3 and SOX10 genes are responsible for Waardenburg syndrome type IV. (review) PMID: 24379252
- Our data showed that almost all patients, regardless of individual characteristics such as gender or age, expressed the endothelin receptor genes, but did not express the genes for ET-3. PMID: 23515723
- These data suggest that autocrine EDN3/EDNRB signaling is essential for maintaining GSCs. Incorporating END3/EDNRB-targeted therapies into conventional cancer treatments may have clinical implication for the prevention of tumor recurrence. PMID: 22013079
- Finding suggest that mutations in RET and NTRK3 acting together are necessary and sufficient for the appearance of Hirschsprung disease and that the EDN3 mutation acts as a phenotype modifier. PMID: 19556619
- EDN3 may be considered as a common susceptibility gene for sporadic Hirschsprung disease in a low-penetrance fashion. PMID: 20009762
- Mutations are found in Hirschsprung's disease in a Chinese population. PMID: 14669347
- KEL6 red blood cells have endothelin-3-converting enzyme activity PMID: 16423827
- neither polymorphism nor mutation was observed in EDN3 in Chinese Hirschprung disease patients PMID: 17554617
- Endothelin-3 molecule is specifically upregulated in metastatic melanoma cells, showing that an abnormal autocrine stimulation pathway involving ET-3 is present in metastatic melanoma cells. PMID: 18346402
- Endothelin signaling axis activates osteopontin expression through PI3 kinase pathway in A375 melanoma cells. PMID: 18722093
- ET3 induced activation of IkappaB & MAPK in epithelial cells. ET3 is involved in regulating human colonic epithelial cell proliferation & survival, particularly for goblet cells. PMID: 18832450
- In conclusion, Multiplex Ligation-dependent Probe Amplification assessment of rearrangements in the RET proto-oncogene and in 3 other associated genes, ZEB2, EDN3 and GDNF did not show any variants in 80 sporadic Hirschsprung disease patients. PMID: 19183406
- Report on spanish cases of Waardenburg syndrome type 4 with novel mutations in EDN3 and SOX 10 genes. PMID: 19764030
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相關疾病：Hirschsprung disease 4 (HSCR4); Congenital central hypoventilation syndrome (CCHS); Waardenburg syndrome 4B (WS4B)
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亞細胞定位：Secreted.
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蛋白家族：Endothelin/sarafotoxin family
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組織特異性：Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
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數據庫鏈接：
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