ECSIT Antibody

說明書

產品詳情

Uniprot No.：

Q9BQ95
基因名：

ECSIT
別名：

Ecsit antibody; ECSIT homolog antibody; ECSIT protein antibody; ECSIT_HUMAN antibody; Evolutionarily conserved signaling intermediate in Toll pathway; mitochondrial antibody; Evolutionarily conserved signaling intermediate in Toll pathways antibody; Likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved antibody; Protein SITPEC antibody; Signaling intermediate in Toll pathway evolutionarily conserved antibody; SITPEC antibody; SITPEC protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Human ECSIT
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,IHC
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.; Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
基因功能參考文獻：
1. mediates virus-triggered type I IFN induction by bridging RIG-I and MDA5 to the VISA complex PMID: 25228397
2. Ubiquitination of ECSIT might have a role in the regulation of NF-kappaB activity in TLR4 signaling. PMID: 25355951
3. Authors conclude that ECSIT appears to be a novel Hepatitis B virus X protein-interacting signal molecule and their interaction is mechanistically important in IL-1beta induction of NF-kappaB activation. PMID: 25449573
4. Data show that the ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) complex, including MEKK7 (TAK1) and TNF receptor-associated factor 6 (TRAF6), plays a role in Toll-like receptor 4 -mediated signals to activate NF-kappa B. PMID: 25371197
5. TRIM59 interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway. PMID: 22588174
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亞細胞定位：

Cytoplasm. Nucleus. Mitochondrion.
蛋白家族：

ECSIT family
數據庫鏈接：

HGNC: 29548

OMIM: 608388

KEGG: hsa:51295

STRING: 9606.ENSP00000270517

UniGene: Hs.515146

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