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DUSP9 Antibody

說明書

產品詳情

Uniprot No.：

Q99956
基因名：

DUSP9
別名：

Dual specificity phosphatase 9 antibody; Dual specificity protein phosphatase 9 antibody; DUS9_HUMAN antibody; DUSP9 antibody; MAP kinase phosphatase 4 antibody; Mitogen activated protein kinase phosphatase 4 antibody; Mitogen-activated protein kinase phosphatase 4 antibody; MKP 4 antibody; MKP-4 antibody; MKP4 antibody; serine/threonine specific protein phosphatase antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human DUSP9
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Inactivates MAP kinases. Has a specificity for the ERK family.
基因功能參考文獻：
1. The results of this study, combined with previous studies, suggested that therapeutic intervention to increase the expression or activity of DUSP9 may enable the activation of anti-proliferation signals in malignant cells. PMID: 25998184
2. A possible use for DUSP9 as CIMP marker. PMID: 24838152
3. DUSP9 protein levels were markedly suppressed in severe pre-eclampsia, but not in severe IUGR. This suppression might be attributable to the prolonged hypoxic conditions found in pre-eclampsia. PMID: 23276385
4. The DUSP9 locus is a common susceptibility locus for type 2 diabetes across different ethnicities, and 6 loci identified in South Asian genome-wide association studies also have significant effect on susceptibility to Japanese type 2 diabetes. PMID: 23029454
5. decreased expression of DUSP-9 is associated with poor prognosis in ccRCC. PMID: 21943117
6. 2.7 A resolution crystal structure of the catalytic domain of MKP-4 (MKP-4C) is presented PMID: 21206059
7. microtubule disruption by MKP4 provides a novel mechanism for tumor suppression by a cytosolic MKP PMID: 18006813
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亞細胞定位：

Cytoplasm.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
數據庫鏈接：

HGNC: 3076

OMIM: 300134

KEGG: hsa:1852

STRING: 9606.ENSP00000345853

UniGene: Hs.144879

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