DPP8 Antibody
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中文名稱：DPP8兔多克隆抗體
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貨號：CSB-PA007142GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：DPP8
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別名：Dipeptidyl peptidase 8 antibody; Dipeptidyl peptidase IV-related protein 1 antibody; Dipeptidyl peptidase VIII antibody; Dipeptidylpeptidase 8 antibody; DP8 antibody; DPP VIII antibody; Dpp8 antibody; DPP8_HUMAN antibody; DPRP-1 antibody; DPRP1 antibody; EC 3.4.14.5 antibody; MSTP141 antibody; Prolyl dipeptidase DPP8 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human DPP8
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (Probable). Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism.
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基因功能參考文獻：
- The DPP8 expressing cell model system is a very useful and promising system for investigating the selectivity and associated toxicity of DPP4 inhibitors on DPP8. PMID: 25464020
- The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. PMID: 24072711
- Suggest roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis. PMID: 23704821
- DPP8 was found in macrophages of carotid atherosclerotic plaque and may play a role in disease progression. PMID: 23608773
- analysis of dipeptidyl peptidases 8 and 9 reveals that they may have compensatory roles PMID: 23519473
- this study demonstrates for the first time that DP8 and DP9 are expressed in breast and ovarian carcinoma cell lines PMID: 22736146
- Data identify modification points in the topology of a representative DPP8/9-inhibitor, capable of rendering selectivity for DPP8 over DPP9. PMID: 21711053
- This is the first study to demonstrate the presence of DP8 in chronic lymphocytic leukemia (CLL) and the upregulation of DP8 mRNA in CLL. PMID: 20534982
- DPP8 and DPP9 prevail over canonical DPP-IV/CD26 and FAPalpha in all examined meningioma patients PMID: 20043068
- cells overexpressing DP8 exhibit behavioral changesin the presence of ECM components; these effects were independent of enzyme activity PMID: 16700509
- Dipeptidyl peptidase 8 and dipeptidyl peptidase 9 influence cell-extracellular matrix interactions, and thus may regulate tissue remodeling. PMID: 16704418
- study has identified the residues absolutely required for the optimal activity of DPP8 and its unique substrate specificity PMID: 17040910
- DP8 cleavage of the N-terminal two residues of IP10 (CXCL10), ITAC (CXCL11) and SDF-1 (CXCL12), is reported. PMID: 18275857
- DP8 and DP9 tissue and cellular expression PMID: 19581630
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亞細胞定位：Cytoplasm.
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蛋白家族：Peptidase S9B family, DPPIV subfamily
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組織特異性：Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain.
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數據庫鏈接：
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