DLX1 Antibody

中文名稱：

DLX1兔多克隆抗體
貨號：

CSB-PA006952LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of Hela cells with CSB-PA006952LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DLX1 Polyclonal antibody
Uniprot No.：

P56177
基因名：

DLX1
別名：

DII B antibody; Distal less homeo box 1 antibody; Distal less homeobox 1 antibody; Distal-less homeobox gene 1a antibody; Dlx 1 antibody; Dlx antibody; Dlx1 antibody; Dlx1 distal-less homeobox 1 antibody; DLX1_HUMAN antibody; Homeo box protein DLX1 antibody; Homeobox protein DLX 1 antibody; Homeobox protein DLX-1 antibody; Homeobox protein Dlx1a antibody; Homeodomain transcription factor DLX1 antibody; MGC189409 antibody; OTTHUMP00000082494 antibody; OTTHUMP00000082497 antibody; OTTMUSP00000014202 antibody; RP23-419H3.3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Homeobox protein DLX-1 protein (8-114AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DLX1 Antibody (CSB-PA006952LA01HU)，的標記方式是Non-conjugated。對于DLX1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA006952LB01HU	DLX1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA006952LC01HU	DLX1 Antibody, FITC conjugated
Biotin	CSB-PA006952LD01HU	DLX1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.
基因功能參考文獻：
1. observations suggest that altered DLX1 methylation and expression contribute to pathogenesis of PSP by influencing MAPT. PMID: 30050033
2. Our results provided evidence that polymorphisms in TIMP1, DLX1 and DLX2 genes may be associated with DF phenotypes. PMID: 28131910
3. DLX1 mRNA levels were shown to be good predictors for the detection of High-grade Prostate Cancer. PMID: 27108162
4. these data strongly suggest that DLX1 has a pivotal role in FOXM1 signaling to promote cancer aggressiveness through intensifying TGF-beta/SMAD4 signaling in high-grade serous ovarian cancer cells. PMID: 27593933
5. TDT results showed an association between DLX1 and cleft lip and palate, in which the A allele was undertransmited (p=0.022). PMID: 25463899
6. The study data demonstrate an association between SNP rs7888172 of the DLX1 gene and non-syndromic hypodontia in Chinese Han individuals. PMID: 22984994
7. The regulation of fate switch between cortical and striatal interneurons is dependent on Dlx1 (and Dlx2). PMID: 23312518
8. These findings suggest that alterations in DLX1/2 contribute to the biological consequences of FLT3 activation. PMID: 21357706
9. DLX1 may function as a regulator of multiple signals from TGF-beta superfamily members in broad biological contexts during blood production PMID: 14671321
10. The DLX1 and DLX2 genes lie head-to-head in 2q32; the findings support the presence of two functional polymorphisms, one in or near each of the DLX genes that increase susceptibility to, or cause, autism. PMID: 18728693
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亞細胞定位：

Nucleus.
蛋白家族：

Distal-less homeobox family
組織特異性：

Expressed in hematopoietic cell lines.
數據庫鏈接：

HGNC: 2914

OMIM: 600029

KEGG: hsa:1745

STRING: 9606.ENSP00000354478

UniGene: Hs.407015

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