Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.
基因功能參考文獻:
observations suggest that altered DLX1 methylation and expression contribute to pathogenesis of PSP by influencing MAPT. PMID: 30050033
Our results provided evidence that polymorphisms in TIMP1, DLX1 and DLX2 genes may be associated with DF phenotypes. PMID: 28131910
DLX1 mRNA levels were shown to be good predictors for the detection of High-grade Prostate Cancer. PMID: 27108162
these data strongly suggest that DLX1 has a pivotal role in FOXM1 signaling to promote cancer aggressiveness through intensifying TGF-beta/SMAD4 signaling in high-grade serous ovarian cancer cells. PMID: 27593933
TDT results showed an association between DLX1 and cleft lip and palate, in which the A allele was undertransmited (p=0.022). PMID: 25463899
The study data demonstrate an association between SNP rs7888172 of the DLX1 gene and non-syndromic hypodontia in Chinese Han individuals. PMID: 22984994
The regulation of fate switch between cortical and striatal interneurons is dependent on Dlx1 (and Dlx2). PMID: 23312518
These findings suggest that alterations in DLX1/2 contribute to the biological consequences of FLT3 activation. PMID: 21357706
DLX1 may function as a regulator of multiple signals from TGF-beta superfamily members in broad biological contexts during blood production PMID: 14671321
The DLX1 and DLX2 genes lie head-to-head in 2q32; the findings support the presence of two functional polymorphisms, one in or near each of the DLX genes that increase susceptibility to, or cause, autism. PMID: 18728693