CST1 Antibody

說明書

中文名稱：

CST1兔多克隆抗體
貨號：

CSB-PA006088ESR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA006088ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human salivary gland tissue using CSB-PA006088ESR1HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CST1 Polyclonal antibody
Uniprot No.：

P01037
基因名：

CST1
別名：

CST1 antibody; Cystain SAI antibody; Cystain-SA-I antibody; Cystatin 1 antibody; Cystatin-1 antibody; Cystatin-SN antibody; Cystatin1 antibody; Cysteine proteinase inhibitor, type 2 family antibody; CYTN antibody; CYTN_HUMAN antibody; Salivary cystatin SA1 antibody; Salivary cystatin-SA-1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Cystatin-SN protein (20-141AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
基因功能參考文獻：
1. Results revealed that CST1 expression was upregulated in colon cancer (CC) compared with normal tissues and contributed to CC cell proliferation. PMID: 29845224
2. High CST1 expression is negatively correlated with survival of breast cancer patients. CST1 promotes cell proliferation, clone formation, and metastasis in breast cancer cells. CST1 is a novel potential prognostic biomarker and therapeutic target for breast cancer. PMID: 28523467
3. this results identified cystatin 1 as a biomarker in patients with seasonal allergic rhinitis PMID: 28633877
4. These results indicate that CST1-mediated extracellular CatB activity enhances tumor development by preventing cellular senescence. PMID: 28383558
5. interactions of human family 1 & 2 cystatins with cathepsin L1 PMID: 27764212
6. high expression of Cystatin SN is a significant prognostic indicator of a higher rate of recurrence, metastatic risk, and poor survival in patients with surgically resected NSCLCs. PMID: 25648368
7. In conclusion, our data suggest that CST1 might contribute to the proliferation of pancreatic cancer cells and could be a potential biomarker for the early detection of pancreatic cancer. PMID: 25577248
8. CST1 may contribute to inactivation of protease allergens and help re-establish homeostasis of the nasal membranes. PMID: 23950865
9. CST1 expression at both the messenger RNA and protein levels was barely detected in control cells, which included early passage proliferating, quiescent, or immortal human fibroblasts PMID: 21636832
10. Murine monoclonal antibodies were made which can distinguish between CST1 and CST2. PMID: 15829315
11. CST1 might be highly involved in gastric tumorigenesis and regulate the proteolytic activity of cysteine proteases. PMID: 19463800
12. Identification of Cystatin SN as a novel tumor marker for colorectal cancer. PMID: 19513549
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亞細胞定位：

Secreted.
蛋白家族：

Cystatin family
組織特異性：

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.
數據庫鏈接：

HGNC: 2473

OMIM: 123855

KEGG: hsa:1469

STRING: 9606.ENSP00000305731

UniGene: Hs.123114

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