Human Cystatin-SN(CST1) ELISA kit

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中文名稱：

人胱抑素SN(CST1)酶聯免疫試劑盒
貨號：

CSB-EL006088HU
規格：

96T/48T
價格：

￥3600/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star? Award in the ELISA category

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產品描述：

人胱抑素SN(CST1)酶聯免疫試劑盒（CSB-EL006088HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液,尿液、組織勻漿、細胞裂解物樣本中的CST1含量。CST1（胱抑素C）是一種分泌蛋白，屬于胱抑素家族，具有抑制組織蛋白酶活性的功能。在腫瘤生長、血管生成、浸潤和轉移中起重要作用。通過生物信息學分析，研究人員揭示了CST1在乳腺癌等癌癥中的潛在作用機制，為癌癥診斷和治療提供了新的靶點。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，科研領域可用于探究CST1在黏膜防御機制、炎癥相關信號通路或腫瘤微環境中的生物學功能，也可作為研究慢性炎癥性疾病、黏膜屏障功能障礙或腫瘤標志物篩選的工具，為疾病機制研究提供數據支持。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

CST1 ELISA Kit; Cystain SAI ELISA Kit; Cystain-SA-I ELISA Kit; Cystatin 1 ELISA Kit; Cystatin-1 ELISA Kit; Cystatin-SN ELISA Kit; Cystatin1 ELISA Kit; Cysteine proteinase inhibitor, type 2 family ELISA Kit; CYTN ELISA Kit; CYTN_HUMAN ELISA Kit; Salivary cystatin SA1 ELISA Kit; Salivary cystatin-SA-1 ELISA Kit
縮寫：

CST1
Uniprot No.：

P01037
種屬：

Homo sapiens (Human)
樣本類型：

serum, plasma, cell culture supernates,urine, tissue homogenates, cell lysates
檢測范圍：

0.156 ng/mL-10 ng/mL
靈敏度：

0.039 ng/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Cell Biology
測定原理：

quantitative
測定方法：

Sandwich
精密度：
線性度：
回收率：
標準曲線：
數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

引用文獻

Cystatin C and cystatin SN as possible soluble tumor markers in malignant uveal melanoma MA Dikovskaya,Radiology and oncology,2023
The Cystatin C and cystatin SN as possible soluble tumor markers in malignant uveal melanoma T Korolenko,Radiology and oncology,2023
Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway X Lisha,e-aair,2023
Endogenous inhibitors of cysteine proteases cystatin C and cystatin SN in biological fluids of patients with intraocular melanoma as possible biomarkers and therapy targets Dikovskaya M.et al,EJC Supplements,2015
P43: Endogenous inhibitors of cysteine proteases cystatin C and cystatin SN in biological fluids of patients with intraocular melanoma as possible biomarkers and ? M. Dikovskaya. et al,European Journal of Cancer Supplements,2015
Identification of cystatin SN as a novel biomarker for pancreatic cancer. Jiang J.et al,Tumour Biol.,2015
Salivary Composition Is Associated with Liking and Usual Nutrient Intake Méjean C. et al,PLoS One,2015
Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the neonatal period are associated to specific saliva composition Morzel M. et al,J Proteomics,2015
Caffeine increases the expression of cystatin SN in human submandibular acinar-like HSG cells Dsamou M et al,Arch Oral Biol,2013

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靶點詳情

功能：

Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
基因功能參考文獻：
1. Results revealed that CST1 expression was upregulated in colon cancer (CC) compared with normal tissues and contributed to CC cell proliferation. PMID: 29845224
2. High CST1 expression is negatively correlated with survival of breast cancer patients. CST1 promotes cell proliferation, clone formation, and metastasis in breast cancer cells. CST1 is a novel potential prognostic biomarker and therapeutic target for breast cancer. PMID: 28523467
3. this results identified cystatin 1 as a biomarker in patients with seasonal allergic rhinitis PMID: 28633877
4. These results indicate that CST1-mediated extracellular CatB activity enhances tumor development by preventing cellular senescence. PMID: 28383558
5. interactions of human family 1 & 2 cystatins with cathepsin L1 PMID: 27764212
6. high expression of Cystatin SN is a significant prognostic indicator of a higher rate of recurrence, metastatic risk, and poor survival in patients with surgically resected NSCLCs. PMID: 25648368
7. In conclusion, our data suggest that CST1 might contribute to the proliferation of pancreatic cancer cells and could be a potential biomarker for the early detection of pancreatic cancer. PMID: 25577248
8. CST1 may contribute to inactivation of protease allergens and help re-establish homeostasis of the nasal membranes. PMID: 23950865
9. CST1 expression at both the messenger RNA and protein levels was barely detected in control cells, which included early passage proliferating, quiescent, or immortal human fibroblasts PMID: 21636832
10. Murine monoclonal antibodies were made which can distinguish between CST1 and CST2. PMID: 15829315
11. CST1 might be highly involved in gastric tumorigenesis and regulate the proteolytic activity of cysteine proteases. PMID: 19463800
12. Identification of Cystatin SN as a novel tumor marker for colorectal cancer. PMID: 19513549
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亞細胞定位：

Secreted.
蛋白家族：

Cystatin family
組織特異性：

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.
數據庫鏈接：

HGNC: 2473

OMIM: 123855

KEGG: hsa:1469

STRING: 9606.ENSP00000305731

UniGene: Hs.123114

Human Cystatin-SN(CST1) ELISA kit

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