CRNN Antibody

中文名稱：

CRNN兔多克隆抗體
貨號：

CSB-PA005988HA01HU
規格：

￥440
圖片：
Western blot
All lanes: CRNN antibody at 12µg/ml
Lane 1: HepG2 whole cell lysate
Lane 2: Mouse heart tissue
Lane 3: Rat skeletal muscle tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CRNN Polyclonal antibody
Uniprot No.：

Q9UBG3
基因名：

CRNN
別名：

53 kDa putative calcium binding protein antibody; 53 kDa putative calcium-binding protein antibody; 53 kDa squamous epithelial induced stress protein antibody; 53 kDa squamous epithelial-induced stress protein antibody; 58 kDa heat shock protein antibody; C1orf10 antibody; Chromosome 1 open reading frame 10 antibody; Cornulin antibody; CRNN antibody; CRNN_HUMAN antibody; DRC1 antibody; PDRC1 antibody; SEP53 antibody; Squamous epithelial heat shock protein 53 antibody; Tumor related protein antibody; Tumor-related protein antibody
宿主：

Rabbit
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human Cornulin protein (139-389AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CRNN Antibody (CSB-PA005988HA01HU)，的標記方式是Non-conjugated。對于CRNN Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA005988HB01HU	CRNN Antibody, HRP conjugated	ELISA
FITC	CSB-PA005988HC01HU	CRNN Antibody, FITC conjugated
Biotin	CSB-PA005988HD01HU	CRNN Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways.
基因功能參考文獻：
1. This study showed a significant correlation between LOH/MSI at 1q21.3 with clinical outcomes and that downregulation of CRNN gene could be considered as a prognostic marker of OSCC. PMID: 25846277
2. The single-nucleotide polymorphisms of CRNN (rs941934) and RPTN (rs3001978, rs28441202) may contribute to Atopic Dermatitis development, but further studies on a larger group of Atopic Dermatitis patients are needed to verify this assumption. PMID: 28219068
3. Loss of CRNN expression correlated with advanced tumor length, greater tumor invasion depth, lymph node metastasis, and poor survival in patients with esophageal squamous cell carcinoma. PMID: 24263008
4. Findings demonstrate that CRNN is a tumor suppressor gene that plays a critical tumor suppressive role in ESCC. PMID: 23894350
5. cornulin is an important molecule in normal esophageal pathology and is likely lost during the conversion of normal to neoplastic epithelium PMID: 22560086
6. SEP53 may be a component of the mucosal/epithelial innate immune response engaged in an ongoing interaction with a pathogen PMID: 17925851
7. Results describe the cloning of porcine SEP53, its homology to the human protein, and its expression in the esophagus and in gastric squamous epithelium. PMID: 18465210
8. CRNN mRNA expression is decreased in eczematous skin PMID: 19133922
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亞細胞定位：

Cytoplasm. Note=Does not colocalize with TGM1.
蛋白家族：

S100-fused protein family
組織特異性：

Expressed in the basal skin layer (at protein level). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular l
數據庫鏈接：

HGNC: 1230

OMIM: 611312

KEGG: hsa:49860

STRING: 9606.ENSP00000271835

UniGene: Hs.242057

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