COG6 Antibody

中文名稱：

COG6兔多克隆抗體
貨號(hào)：

CSB-PA23419A0Rb
規(guī)格：

￥440
圖片：
IHC image of CSB-PA23419A0Rb diluted at 1:500 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) COG6 Polyclonal antibody
Uniprot No.：

Q9Y2V7
基因名：

COG6
別名：

CDG2L antibody; COD2 antibody; COG complex subunit 6 antibody; COG6 antibody; COG6_HUMAN antibody; Complexed with Dor1p 2 antibody; Component of oligomeric Golgi complex 6 antibody; Conserved oligomeric Golgi complex component 6 antibody; Conserved oligomeric Golgi complex protein 6 antibody; Conserved oligomeric Golgi complex subunit 6 antibody; KIAA1134 antibody; SHNS antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Conserved oligomeric Golgi complex subunit 6 protein (556-653AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，COG6 Antibody (CSB-PA23419A0Rb)，的標(biāo)記方式是Non-conjugated。對(duì)于COG6 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA23419B0Rb	COG6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA23419C0Rb	COG6 Antibody, FITC conjugated
Biotin	CSB-PA23419D0Rb	COG6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶點(diǎn)詳情

功能：

Required for normal Golgi function.
基因功能參考文獻(xiàn)：
1. COG6 is a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus. PMID: 27193031
2. study presents 7 additional patients with 4 novel COG6 mutations; genotype-phenotype correlation can be discerned ranging from deep intronic mutations found in Shaheen syndrome as the mildest form to loss-of-function mutations leading to early lethal congenital disorders of glycosylation phenotypes PMID: 26260076
3. The aim of this study was to investigate whether the HCP5, TNIP1, TNFAIP3, SPATA2 and COG6 genes were genetic risk factors for psoriasis in Chinese population. PMID: 25264125
4. Our findings implicate COG6 rs9548934C-->T genotypes and circulating miRNA-1 phenotype in modulating the occurrence and major adverse cardiovascular events of coronary artery disease. PMID: 25197382
5. Targeted silencing of components of lobe B of the COG complex, namely COG5, COG6, COG7 and COG8, inhibited HIV-1 replication PMID: 25179963
6. data implicate COG6 in the pathogenesis of a novel hypohidrotic disorder in humans that is distinct from congenital disorders of glycosylation. PMID: 23606727
7. COG6 interaction with SNARE proteins via universal SNARE-binding motif of COG6 is important for Golgi complex intergrity. PMID: 23057818
8. COG6 rs9548934C-->T polymorphism is associated with lower risk of premature coronary artery disease, especially in female subjects and subjects with lower serum lipid levels. PMID: 22883088
9. COG directly and positively regulates endosome-to-TGN retrograde transport by specific and direct interaction with the t-SNARE Stx6 via its Cog6 subunit. PMID: 21807881
10. This paper reports a new congenital disorder caused by mutations in the human COG8 gene and describes the affect this mutation has on the other COG components. PMID: 17331980
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相關(guān)疾病：

Congenital disorder of glycosylation 2L (CDG2L); Shaheen syndrome (SHNS)
亞細(xì)胞定位：

Golgi apparatus membrane; Peripheral membrane protein.
蛋白家族：

COG6 family
數(shù)據(jù)庫鏈接：

HGNC: 18621

OMIM: 606977

KEGG: hsa:57511

STRING: 9606.ENSP00000397441

UniGene: Hs.507805

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