CLDN14 Antibody
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中文名稱：CLDN14兔多克隆抗體
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貨號：CSB-PA005494ESR1HU
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規格：￥440
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圖片：
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Western blot
All lanes: Claudin-14 antibody at 4μg/ml
Lane 1: Rat liver tissue
Lane 2: Mouse kidney tissue
Lane 3: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 26 kDa
Observed band size: 26 kDa -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005494ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA005494ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品描述：
The polyclonal CLDN14 antibody is raised in rabbits against the recombinant human CLDN14 protein (140-239AA). It occurs as an unconjugated IgG. It underwent antigen affinity purified. And it shows reactivity with CLDN14 of human-, mouse-, and rat-origin. The target protein CLDN14 is important for the physiology of cochlear hair cells in the inner ear. Studies found that dysregulation of the renal CaSR-CLDN14 pathway could contribute significantly to the development of hypercalciuria, and hence the generation of kidney stones and osteoporosis. This anti-CLDN14 antibody can be used to recognize the CLDN14 protein in ELISA, WB, and IHC applications.
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產品名稱：Rabbit anti-Homo sapiens (Human) CLDN14 Polyclonal antibody
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Uniprot No.：
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基因名：CLDN14
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別名：CLDN14; UNQ777/PRO1571; Claudin-14
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宿主：Rabbit
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反應種屬：Human, Mouse, Rat
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免疫原：Recombinant Human Claudin-14 protein (140-239AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:200-1:1000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
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基因功能參考文獻：
- This study suggested considerable genetic heterogeneity in the causation of hearing loss in Dhadkai. Recessive mutations were observed in at least three genes causing hearing loss: OTOF (p.R708X), SLC26A4 (p.Y556X) and CLDN14 (p.V85D). Mutation p.R708X appeared to be the major cause of hearing impairment in Dhadkai. PMID: 29434063
- CLDN14 might not be a major causative gene for NSHL in Chinese populations, which would contribute to fully understanding the genetic cause of NSHL in the East Asian populations PMID: 29447821
- Our data suggest that children with the INSM1 binding site within the CLDN14 risk haplotype have a higher likelihood of hypercalciuria and kidney stones. Enhanced CLDN14 expression may play a role in the pathophysiology of their hypercalciuria. PMID: 28229505
- All hearing impaired individuals, including the proband, are homozygous for a pathogenic variant of CLDN14, but this only explains the deafness. PMID: 27629923
- Extensive clinical recruitment and targeted screening suggest that CLDN14 p.(Ala163Val) represents a major founder variant for prelingual sensorineural hearing loss in the Newfoundland population. PMID: 27838790
- CLDN14 is a novel direct target of EZH2-mediated H3K27ME3 and plays role in EZH2-H3K27ME3-mediated hepatocellular carcinoma aggressiveness. PMID: 27207647
- The rs170183 was correlated with a decline in claudin 14 expression in both lymphoblastoid cell lines and T cells. PMID: 26842849
- Rs1801725 (Ala986-Ser), rs1042636 (Arg990Gly) of CaSR gene and rs219778, rs219780 (Thr229Thr) of CLDN14 gene were significantly associated with kidney stone disease in patients from the Eastern part of India. PMID: 26107257
- Claudin 14 expression was up-regulated in gastric cancer. PMID: 24325792
- Data suggest a possible role for Claudin14 in urinary calcium excretion. PMID: 23991001
- CLDN14 mutations can contribute to the aetiology of childhood/congenital deafness in Moroccan patients. PMID: 23590985
- Human Cldn-8 and -14 were shown to convey Clostridium perfringens enterotoxin-mediated cytotoxicity at pathophysiologically relevant concentrations of this toxin, although ~2-to-10-fold less efficiently than Cldn-4. PMID: 23322640
- OPRM1 genetic polymorphisms are associated with the plasma concentration of cotinine in a Taiwanese MMT cohort. Carriers with the major allele of SNP rs1799971 had a higher plasma cotinine concentration. PMID: 23235333
- The hearing loss due to novel CLDN14 mutations is prelingual, severe-to-profound with greater loss in the high frequencies. PMID: 22246673
- The CLDN14 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
- Individuals with mutations of CLDN14 may have different degrees of hearing loss and the loss is greater at higher frequencies. PMID: 20811388
- The palmitoylation of claudin-14 is required for efficient localization into tight junctions but not stability or strand assembly. PMID: 15769849
- The ability of CLDN14 to be recruited to these junctions is crucial for the hearing process. PMID: 15880785
- Common, synonymous variants in the CLDN14 gene that associate with kidney stones, were discovered. PMID: 19561606
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相關疾病：Deafness, autosomal recessive, 29 (DFNB29)
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亞細胞定位：Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
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蛋白家族：Claudin family
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組織特異性：Liver, kidney. Also found in ear.
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數據庫鏈接：
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