CD109 Antibody

中文名稱：

CD109兔多克隆抗體
貨號：

CSB-PA740988LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA740988LA01HU diluted at 1:200 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA740988LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CD109 Polyclonal antibody
Uniprot No.：

Q6YHK3
基因名：

CD109
別名：

150 KDa TGF beta 1 binding protein antibody; 150 KDa TGF-beta-1-binding protein antibody; 7D1 antibody; 8A3 antibody; Activated T cell marker CD109 antibody; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7 antibody; CD 109 antibody; CD109 antibody; CD109 antigen antibody; CD109_HUMAN antibody; CPAMD7 antibody; DKFZp762L1111 antibody; E123 antibody; FLJ38569 antibody; FLJ41966 antibody; Gov system alloantigens on platelets antibody; p180 antibody; Platelet specific Gov antigen antibody; Platelet-specific Gov antigen antibody; r150 antibody; RP11 525G3.1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human CD109 antigen protein (967-1122AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CD109 Antibody (CSB-PA740988LA01HU)，的標記方式是Non-conjugated。對于CD109 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA740988LB01HU	CD109 Antibody, HRP conjugated	ELISA
FITC	CSB-PA740988LC01HU	CD109 Antibody, FITC conjugated
Biotin	CSB-PA740988LD01HU	CD109 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Modulates negatively TGFB1 signaling in keratinocytes.
基因功能參考文獻：
1. GRP78 binds to and acts in concert with a glycosylphosphatidylinositol-anchored protein, CD109, in blocking TGF-beta signaling by promoting the routing of the TGF-beta receptor to the caveolae, thereby disrupting its binding to and activation of Smad2. PMID: 29654145
2. CD109 knockdown upregulated IL-8 expression through activation of TGF-beta/Akt/NF-kappaB pathway in human umbilical vein endothelial cells PMID: 27121053
3. High expression of CD109 in brain tumor stem cells is involved in glioma progression. PMID: 28888050
4. The CD109 protein was up-regulated in hepatocellular carcinoma tissue compared with adjacent noncancerous tissue. CD109 shRNA knockdown delayed the G1-S phase transition, abrogated cell proliferation, and increased cell apoptosis. Furthermore, CD109 impaired TGF-beta/Smad signaling through control of p-smad2. PMID: 27074923
5. CD109 is a putative biomarker for identifying a high-risk group among DLBCL patients. PMID: 28032275
6. Expression levels of CD109 was reduced significantly in psoriasis. Lower expression of CD109 and TGF-beta RI was highly correlated with higher expression of Smad7 and Ki67, suggesting that CD109 may induce the pathogenesis of psoriasis through Smad7-mediated degradation of TGF-beta RI. PMID: 26838754
7. sCD109 can bind TGF-beta, inhibit TGF-beta binding to its receptors and decrease TGF-beta signalling and TGF-beta-induced cellular responses. PMID: 26621871
8. These findings indicate that CD109 is an exosomal protein and that the C-terminal region of CD109 is required for its presence in the exosome. PMID: 26707640
9. CD109 may be a potential pathology marker for gallbladder squamous cell/adenosquamous carcinomas. PMID: 26249215
10. CD109 is specifically expressed in endothelial cells of cutaneous cavernous haemangioma. PMID: 25388101
11. expression increased in cutaneous squamous cell carcinoma PMID: 25271095
12. The results suggest that circulating endothelial cells express CD109 and represent a rare population of circulating tumor endothelial cells, that play a potentially useful prognostic role in patients with glioblastoma. PMID: 25506915
13. CD109 overexpression was significantly associated with surgical stage, distant metastasis, and poor prognosis in myxofibrosarcoma. PMID: 26031650
14. Three glioblastoma cell lines, SK-MG-1, U251MG and MG178, were tested and CD109 overexpression attenuated TGF-beta1 signaling and enhanced EGF signaling in SK-MG-1, but not in U251MG or MG178. PMID: 25724945
15. CD109 is highly expressed in TNBC and is a potential biomarker for the initiation, progression, and differentiation of breast cancer tumors. PMID: 25149155
16. CD109 plays a critical role in non-small-cell lung cancer (NSCLC) progression, and is overexpressed in advanced NSCLC PMID: 24667143
17. High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in a novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma. PMID: 24376795
18. Hematopoietic cell marker CD109 is expressed in hepatic progenitor cells. PMID: 24396288
19. expression of CD109 (human platelet antigen 15) mRNA is different in various human cell types PMID: 23509816
20. The upregulation of CD109 protein in SSc may represent an adaptation or consequence of aberrant TGF-beta signaling in systemic sclerosis PMID: 22694813
21. CD109 is an important regulator of SMAD7/Smurf2-mediated degradation of TGFBR1. PMID: 21898545
22. CD109 release from the cell surface in human keratinocytes regulates TGF-beta receptor expression, TGF-beta signalling and STAT3 activation. PMID: 21539622
23. CD109 regulates TGF-beta receptor endocytosis and degradation to inhibit TGF-beta signaling. PMID: 21295082
24. Report PRSS3/mesotrypsin upregulation in breast cancer cells and identify CD109 as the functional proteolytic target of mesotrypsin. PMID: 20035377
25. These findings suggest that CD109 is involved in bladder tumorigenesis and is a potential target for cancer immunotherapy. PMID: 20946523
26. Processing of CD109 into 180 kDa and 25 kDa proteins by furin, followed by complex formation with the type I TGF-beta receptor is required for the regulation of TGF-beta signaling in cancer cells and keratinocytes. PMID: 20101215
27. Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins. cDNA sequence determination and protein structure analysis given. PMID: 11861284
28. A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens. PMID: 11861285
29. Findings suggest that CD109 may become a molecular target for the development of new therapeutics for squamous cell carcinoma of various tissue origins. PMID: 15826242
30. CD109 plays a unique role in the regulation of isoform-specific TGF-beta signaling in keratinocytes. PMID: 16754747
31. Findings indicate that CD109 is a useful marker for the diagnosis of invasive breast and prostate carcinomas. PMID: 17493171
32. the novel gene HEPT3 may function through its noncoding RNA and its overexpression may play a role in hepatocarcinogenesis [HEPT3] PMID: 17611685
33. CD109 expression may play a role in the development of lung squamous cell carcinoma. PMID: 17922683
34. Up-regulation of CD109 expression is associated with carcinogensis of the squamous epithelium of the oral cavity. PMID: 19016750
35. Found with a mutation in 7% of colon cancers studied. PMID: 16959974
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

Protease inhibitor I39 (alpha-2-macroglobulin) family
組織特異性：

Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and act
數據庫鏈接：

HGNC: 21685

OMIM: 608859

KEGG: hsa:135228

STRING: 9606.ENSP00000287097

UniGene: Hs.399891

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