CACNA2D2 Antibody

文獻引用 (1) 說明書

中文名稱：

CACNA2D2兔多克隆抗體
貨號：

CSB-PA889145ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: CACNA2D2 antibody IgG at 4.51μg/ml + Mouse brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 130, 123, 131 kDa
Observed band size: 130 kDa

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA889145ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA889145ESR2HU at dilution of 1:100
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CACNA2D2 Polyclonal antibody
Uniprot No.：

Q9NY47
基因名：

CACNA2D2
別名：

Alpha 2 delta calcium channel subunit antibody; CA2D2_HUMAN antibody; CACNA2D antibody; Cacna2d2 antibody; Calcium channel, voltage-dependent, alpha 2/delta subunit 2 antibody; Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26 antibody; Calcium voltage gated channel auxiliary subunit alpha2delta 2 antibody; Gene 26 antibody; KIAA0558 antibody; LUAC11.1 antibody; Voltage-dependent calcium channel subunit alpha-2/delta-2 antibody; Voltage-dependent calcium channel subunit delta-2 antibody; Voltage-gated calcium channel subunit alpha-2/delta-2 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-2 protein (20-200AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Global DNA methylation pattern involved in the modulation of differentiation potential of adipogenic and myogenic precursors in skeletal muscle of pigs Zhang, X,Stem Cell Research & Therapy,2020

產品評價

靶點詳情

功能：

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
基因功能參考文獻：
1. show that the action of alpha2delta2 on tumor development occurs not only through a stimulation of proliferation PMID: 25619833
2. The investigation of single nucleotide polymorphisms in three genes that have a functional impact on the opioid response: OPRM1, ABCB1 and the calcium channel complex subunit CACNA2D2, is reported. PMID: 23402298
3. CACNA2D2 deletion/methylation is associated with cervical disease progression. PMID: 21809394
4. single nucleotide polymorphism identified PMID: 11851383
5. role in apoptosis in non-small cell lung cancer cells via association with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity PMID: 12555074
6. In mice, targeted disruption of Cacna2d2 led to growth retardation, reduced life span, ataxia, enhanced susceptibility to seizures, and cardiac abnormalities. Cacna2d2 may be involved in hereditary cerebellar ataxias and epileptic disorders in humans. PMID: 15331424
7. Although transgenic du(2J)/+ mice have a marked reduction in alpha2delta-2 protein, they show no fall in Purkinje somatic calcium currents or increase in cerebellar tyrosine hydroxylase gene expression. PMID: 17135419
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Calcium channel subunit alpha-2/delta family
組織特異性：

Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta an
數據庫鏈接：

HGNC: 1400

OMIM: 607082

KEGG: hsa:9254

STRING: 9606.ENSP00000418081

UniGene: Hs.476273

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