BDKRB2 Antibody

中文名稱：

BDKRB2兔多克隆抗體
貨號：

CSB-PA002652LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: A549 whole cell lysate, MCF-7 whole cell lysate, Hela whole cell lysate
All lanes: BDKRB2 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45, 42 kDa
Observed band size: 55 kDa

Immunofluorescence staining of U-87 cells with CSB-PA002652LA01HU at 1:100, counter-stained with DAPI. The cells were blocked in 10% normal Goat Serum and incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) BDKRB2 Polyclonal antibody
Uniprot No.：

P30411
基因名：

BDKRB2
別名：

BDKRB2; BKR2; B2 bradykinin receptor; B2R; BK-2 receptor
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human B2 bradykinin receptor protein (336-391AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，BDKRB2 Antibody (CSB-PA002652LA01HU)，的標記方式是Non-conjugated。對于BDKRB2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA002652LB01HU	BDKRB2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002652LC01HU	BDKRB2 Antibody, FITC conjugated
Biotin	CSB-PA002652LD01HU	BDKRB2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:200-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
基因功能參考文獻：
1. Study results indicated that the bradykinin B2 receptor-mediated pathway is involved in the cPLA2-related inflammatory response from the PKC pathway in traumatic brain injury. PMID: 29894755
2. The most characteristic signaling pathways for B2R and D2R, dependent on intracellular Ca(2+) and cAMP concentration, respectively, were analyzed in cells presenting similar endogenous expression of B2R and D2R.The evidence of B2R-D2R dimerization may open new perspectives in the modulation of diverse cellular functions which depend on their activation. PMID: 28757212
3. These results indicate that KOR can form a heterodimer with B2R and this leads to increased protein kinase A activity by the CREB signaling pathway, leading to a significant increase in cell proliferation. PMID: 28069442
4. Study demonstrated the ability of long-chain polyunsaturated fatty acids to act as agonist to the B2R at nanomolar concentrations and to induce receptor conformational changes. PMID: 23826374
5. Data suggest that N-myc (and STAT) interactor (NMI) could improve its downstream target bradykinin B2 receptor (BDKRB2) expression to induce extracellular signal-regulated kinases (ERK) 1/2 activation, and thereby further evoke malignant progression of hepatocellular carcinoma (HCC). PMID: 28077802
6. BDKRB2 +9/-9 bp polymorphisms affected the gene expression and nitric oxide production, which were associated with radiographic severity of osteoarthritis, suggesting that the BDKRB2 +9/ -9 bp polymorphisms may act as a genetic modulator of osteoarthritis, and play an essential role in inflammatory process in osteoarthritis. PMID: 26764266
7. Review/Meta-analysis: suggest bradykinin B2 receptor -58C allele and -58CC genotype increase the risk of hypertension in Asians and African-Americans. Inversely, -58TT genotype decreases the risk of hypertension in Asians and African-Americans. PMID: 27007662
8. authors found significant interactions among PRKCA, NOS3 and BDKRB2 genotypes associated with enalapril responses. PMID: 27696692
9. Bronchial B2R expression is constitutively elevated in allergic asthma and is further increased after allergen exposure together with NF-kB expression. PMID: 26588817
10. Report the presence of nuclear B2R in the utero-placental unit and reduced abundance of nuclear B2R in extravillous trophoblast in preeclampsia. PMID: 26955769
11. Data provide evidence that the BDKRB2 +9/-9 polymorphisms influence pro-inflammatory cytokine levels in knee osteoarthritis by altering TLR-2 expression. PMID: 26982743
12. These results suggest that the response to long-term exercise training could be modulated by the BDKRB2 gene -9/+9 polymorphism in male athletes. In well-trained swimmers, BDKRB2 gene variation was not found to be an independent determinant of swimming performance. PMID: 26907838
13. Significant association between the -58T/C polymorphism and the increased risk of Hypertension was found in Northern Han Chinese population. PMID: 26362411
14. Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways. PMID: 26360782
15. Bradykinin receptor B2 (B2R) genetic variation may affect thirst because of effects bradykinin activity. PMID: 25641172
16. These results indicate that B2R couples with P2Y2R and that these G-protein-coupled receptors act together to fine-tune cellular responsiveness. PMID: 25713410
17. The nasal mucosa specimens from chronic rhinosinusitis patients expressed relatively higher B2R and slightly higher kininogen (KNG)/BK and B1R. PMID: 25970620
18. A cross-talk was found between bradykinin B2 receptor and cytokines in retinal pigment epithelium. PMID: 26235941
19. no association between the -9/+9 polymorphism and elite athletic status PMID: 25078958
20. Genetic variation was observed in obese patients with hypertension, obese patients' total cholesterol levels varied by genotype, and waist circumference and blood pressure were elevated in the non-obese having a C/C genotype compared to T/C and T/T. PMID: 25529519
21. Bradykinin receptor B2-VNTR length polymorphism was not associated with angina pectoris and myocardial infarction in Russian men. PMID: 25842860
22. Bradykinin increases IL-6 production via B2R and the ERK pathway, thereby contributing to the invasion and migration of colorectal cancer cells. PMID: 25109623
23. B2 receptor-mediated relaxation reduced in myometrial vessels in pre-eclampsia PMID: 24304135
24. We propose that heterodimerization of bradykinin B2 receptor with lamin C is essential to nuclear localization of bradykinin B2 receptor and plays an important role in cell signaling and function. PMID: 24211782
25. Bradykinin activates multiple signal transduction pathways in human trabecular meshwork cells via B2-receptors that also mediate intraocular pressure reduction PMID: 24236827
26. These results suggest that reflex muscle vasodilation and ACE activity in response to exercise training are modulated by BDKRB gene +9/-9 polymorphism in healthy individuals. PMID: 23613132
27. Bradykinin induces ATP release from human subcutaneous fibroblasts via connexin and pannexin-1-containing hemichannels leading to [Ca2+]i mobilization through the cooperation of B2 and P2Y12 receptors PMID: 24047499
28. Bradykinin induced asthmatic fibroblast/myofibroblast activities via bradykinin B2 receptor and different MAPK pathways. PMID: 23588115
29. Our data suggest that the B -9 allele and reduced ACE activity are associated with both ACE-AE and ACE-cough. PMID: 23730990
30. Dominant negative (GDP-locked)-Rab5 and -Rab11 reproduced the effects of inhibitors of tubulin and actin, respectively, on the cycling of bradykinin B receptor. PMID: 23454239
31. These studies have provided evidence of a functional endogenously expressed B-receptor system in the ciliary muscle that appears to be involved in modulating intraocular pressure. PMID: 23805043
32. there is a higher frequency of the D allele (high plasma ACE activity) and +9 allele (lower B2R expression) in transplant patients compared with control individuals PMID: 23362199
33. Triceps brachii morphological response to targeted strength training--hypertrophy--is related to bradykinin type (BK)2 receptor polymorphisms. PMID: 23127247
34. Our findings suggest that both eNOS and bradykinin B2 receptor genotypes may affect the antihypertensive responses to enalapril. PMID: 22706620
35. In coronary artery disease patients, bradykinin-B2-receptor downregulation on endothelial repair-promoting circulating mononuclear cells substantially impairs bradykinin-dependent endothelial repair. PMID: 23275384
36. results suggest that the co-existence of ACE (D/D), BDKRB2 (+9/-9) or LEP (G/A) genotypes in female athletes might be correlated with a superior level of physical performance PMID: 23176367
37. Suggest that the BDKRB2 +9/-9 polymorphism may act as a genetic modulator of glucose homeostasis and increase susceptibility to diabetes. PMID: 23243416
38. Bradykinin up-regulates B(2) receptor expression (P<0.05) and stimulate IL-8 release (P<0.001) in BEAS-2B cells. PMID: 22935637
39. Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. PMID: 23132855
40. The BDKRB2-58T/C gene polymorphism is associated with increased EH risk. The results of this study suggest that carriers of the -58C allele are susceptible to EH. PMID: 22900090
41. Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCdelta/c-Src dependent signaling pathway. PMID: 22653778
42. The +9/-9 bp polymorphisms of BDKRB2 gene may be used as a genetic marker for the susceptibility and severity of OA. PMID: 23093849
43. expression showed a growing trend with grade of endometrial cancer, reaching the peak in grade 2, whereas grade 3 was characterized by a decrease in transcriptional activity PMID: 22706224
44. Maximakinin is an agonist of the human and rabbit B(2)R with a 8-12 fold lesser potency. PMID: 22108573
45. While -58C>T polymorphism did not reveal any association with essential hypertension, +/-9 bp polymorphism showed a significant association with high risk for heterozygotes (+9/-9) when tested against the pooled frequencies of homozygotes. PMID: 22468762
46. Capillary electrophoresis is a rapid, accurate and sensitive method for genotyping the 9-bp exon 1 insertion/deletion polymorphism in BDKRB2. PMID: 22304584
47. Tested the influence of the interaction between the BDKRB2 -9/+9 and the GNB3 C825T (rs5443) genotypes in relation to endurance performance. There was no interaction between BDKRB2 -9/+9 and GNB3 C825T polymorphisms in relation to endurance. PMID: 21210858
48. Results demonstrate that helix 8 of the B(2)R plays a crucial role not only in efficient trafficking to the plasma membrane or the activation of G proteins but also for the interaction of the B(2)R with GRK2/3 and beta-arrestins. PMID: 22016392
49. Aging cardiac endothelial cells gradually lose their capacity to express BK-2Rs. PMID: 21986469
50. High molecular weight kininogen activates B2 receptor signaling pathway in human vascular endothelial cells. PMID: 21586566
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family, Bradykinin receptor subfamily, BDKRB2 sub-subfamily
組織特異性：

Ubiquitous. Widespread in normal smooth muscle tissue and neurons.
數據庫鏈接：

HGNC: 1030

OMIM: 113503

KEGG: hsa:624

STRING: 9606.ENSP00000307713

UniGene: Hs.654542

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