BAG5 Antibody
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中文名稱：BAG5兔多克隆抗體
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貨號：CSB-PA004680
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規格：￥1090
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圖片：
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Western Blot analysis of Jurkat K562 cells using BAGE5 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：BAG family molecular chaperone regulator 5 antibody; BAG-5 antibody; BAG5 antibody; BAG5_HUMAN antibody; Bcl 2 associated athanogene 5 antibody; Bcl-2-associated athanogene 5 antibody; BCL2 associated athanogene 5 antibody; KIAA0873 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the N-terminal region of Human BAGE5.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
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基因功能參考文獻：
- BAG5 was found as a expression variability marker in an 8-cell human embryo. PMID: 26288249
- Subsequent BAG5 upregulation ameliorated the tumor-suppressive effects of miR-127-3p overexpression in epithelial ovarian cancer (EOC). In conclusion, miR-127-3p functions as a tumor suppressor in EOC, and its influence on EOC is directly through regulation of BAG5. PMID: 27571744
- High BAG5 expression is associated with pancreatic cancer. PMID: 27571739
- This study showed that BAG2 (Bcl-2 associated athanogene family protein 2) and BAG5 (Bcl-2-associated athanogene family protein 5) stabilise pathogenic ataxin3-80Q by inhibiting its ubiquitination. PMID: 25006867
- BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PMID: 24475098
- BAG5 is a binding partners of LRRK2 and part of a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system. PMID: 24510904
- Bag5 is overexpressed in prostate cancer and plays a role in endoplamic reticulum-stress induced apoptosis. Furthermore we have identified GRP78/BiP as a novel interaction partner of Bag5. PMID: 23448667
- BAG5 directly interacts with Parkin and stabilizes Parkin via the ubiquitin-mediated proteasomal pathway. PMID: 21131737
- A novel function for BAG5 as a modulator of CHIP E3 ubiquitin ligase activity with implications for CHIP-mediated regulation of alpha-syn oligomerization. PMID: 21358815
- We replicated the association of BCL2L11 and CASP9 with non-Hodgkin's lymphoma risk at the gene and SNP level, and identified novel associations with BCLAF1 and BAG5. PMID: 20855536
- Bcl-2-associated athanogene 5 (BAG5) is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death. PMID: 15603737
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