BAG5 Antibody, HRP conjugated

說明書

中文名稱：

BAG5兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA890743HB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

產(chǎn)品描述：

CUSABIO uses the recombinant human BAG5 protein (1-447AA) as the immunogen to immunize the rabbit to yield the anti-BAG5 antibody. This resulting polyclonal antibody occurs as an HRP-conjugated IgG. Its purity reaches up to 95% using protein G purified. It only shows reactivity with human BAG5 protein, which is frequently overexpressed in many types of human tumors. BAG5 overexpression is correlated with a poor prognosis. And it has been verified to recognize BAG5 protein in ELISA analysis.
產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) BAG5 Polyclonal antibody
Uniprot No.：

Q9UL15
基因名：

BAG5
別名：

BAG family molecular chaperone regulator 5 antibody; BAG-5 antibody; BAG5 antibody; BAG5_HUMAN antibody; Bcl 2 associated athanogene 5 antibody; Bcl-2-associated athanogene 5 antibody; BCL2 associated athanogene 5 antibody; KIAA0873 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human BAG family molecular chaperone regulator 5 protein (1-447AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
基因功能參考文獻：
1. BAG5 was found as a expression variability marker in an 8-cell human embryo. PMID: 26288249
2. Subsequent BAG5 upregulation ameliorated the tumor-suppressive effects of miR-127-3p overexpression in epithelial ovarian cancer (EOC). In conclusion, miR-127-3p functions as a tumor suppressor in EOC, and its influence on EOC is directly through regulation of BAG5. PMID: 27571744
3. High BAG5 expression is associated with pancreatic cancer. PMID: 27571739
4. This study showed that BAG2 (Bcl-2 associated athanogene family protein 2) and BAG5 (Bcl-2-associated athanogene family protein 5) stabilise pathogenic ataxin3-80Q by inhibiting its ubiquitination. PMID: 25006867
5. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PMID: 24475098
6. BAG5 is a binding partners of LRRK2 and part of a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system. PMID: 24510904
7. Bag5 is overexpressed in prostate cancer and plays a role in endoplamic reticulum-stress induced apoptosis. Furthermore we have identified GRP78/BiP as a novel interaction partner of Bag5. PMID: 23448667
8. BAG5 directly interacts with Parkin and stabilizes Parkin via the ubiquitin-mediated proteasomal pathway. PMID: 21131737
9. A novel function for BAG5 as a modulator of CHIP E3 ubiquitin ligase activity with implications for CHIP-mediated regulation of alpha-syn oligomerization. PMID: 21358815
10. We replicated the association of BCL2L11 and CASP9 with non-Hodgkin's lymphoma risk at the gene and SNP level, and identified novel associations with BCLAF1 and BAG5. PMID: 20855536
11. Bcl-2-associated athanogene 5 (BAG5) is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death. PMID: 15603737
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數(shù)據(jù)庫鏈接：

HGNC: 941

OMIM: 603885

KEGG: hsa:9529

STRING: 9606.ENSP00000338814

UniGene: Hs.5443

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