BAAT Antibody

說明書

中文名稱：

BAAT兔多克隆抗體
貨號：

CSB-PA613484ESR1HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: BAAT antibody IgG at 3.73μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 46 kDa
Observed band size: 46 kDa

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA613484ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA613484ESR1HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) BAAT Polyclonal antibody
Uniprot No.：

Q14032
基因名：

BAAT
別名：

FLJ20300 antibody; BAAT antibody; BAAT_HUMAN antibody; BACAT antibody; BAT antibody; Bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) antibody; Bile acid CoA:amino acid N acyltransferase antibody; Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase antibody; Bile acid Coenzyme A: amino acid N acyltransferase antibody; Bile acid-CoA:amino acid N-acyltransferase antibody; Glycine N choloyltransferase antibody; Glycine N-choloyltransferase antibody; Long chain fatty acyl CoA hydrolase antibody; Long-chain fatty-acyl-CoA hydrolase antibody; MGC104432 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human Bile acid-CoA:amino acid N-acyltransferase protein (309-418AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine. More than 95% of the BAs are N-acyl amidates with glycine and taurine. Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism. This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption. May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.
基因功能參考文獻(xiàn)：
1. BAAT polymorphisms might not be associated with anti-tuberculosis drug-induced hepatotoxicity in the Chinese population PMID: 27155186
2. These results indicate that even small changes in the carboxy terminus of BAAT can have significant effects on activity and substrate specificity PMID: 27230263
3. Case Report: mmunostaining may facilitate diagnosis in bile-acid amidation defects in bile acid-CoA: amino acid N-acyltransferase deficiency. PMID: 22783059
4. there is an essential catalytic triad within hBAT consisting of Cys-235, His-362, and Asp-328 with Cys-235 serving as the probable nucleophile and thus the site of covalent attachment of the bile acid molecule PMID: 12239217
5. Familial hypercholanemia in Amish individuals is associated with mutations in tight junction protein 2 (encoded by TJP2, also known as ZO-2) and bile acid Coenzyme A: amino acid N-acyltransferase (encoded by BAAT). PMID: 12704386
6. cytosolic BACAT enzyme may play important roles in protection against toxicity by accumulation of unconjugated bile acids and non-esterified very long-chain fatty acids PMID: 12810727
7. hBAAT and rBaat are peroxisomal enzymes present in undetectable amounts in the cytosol. Unconjugated or deconjugated bile salts returning to the liver need to shuttle through the peroxisome before reentering the enterohepatic circulation. PMID: 17256745
8. identification of 3 novel SNPs, 147C>T in exon 2 (silent), 602G>C in exon 3 (Arg201Pro) & 1134C>T in exon 4 (silent), in the BAAT gene by resequencing the entire coding region and the exon-intron junctions of 100 Japanese individuals PMID: 17495420
9. Data show that dose-response inactivation by 4HNE (4-hydroxynonenal) of hBAT (human bile acid CoA:amino acid N-acyltransferase) and CKBB (cytosolic brain isoform of creatine kinase) is associated with site-specific modifications. PMID: 18793185
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相關(guān)疾病：

Familial hypercholanemia (FHCA)
亞細(xì)胞定位：

Cytoplasm, cytosol. Peroxisome.
蛋白家族：

C/M/P thioester hydrolase family
組織特異性：

Expressed in liver, gallbladder mucosa and pancreas.
數(shù)據(jù)庫鏈接：

HGNC: 932

OMIM: 602938

KEGG: hsa:570

STRING: 9606.ENSP00000259407

UniGene: Hs.284712

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