AMPH Antibody

說明書

中文名稱：

AMPH兔多克隆抗體
貨號：

CSB-PA011032
規格：

￥1090
圖片：
Western Blot analysis of HeLa cells using Amphiphysin I Polyclonal Antibody

Western Blot analysis of NIH-3T3 cells using Amphiphysin I Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P49418
基因名：

AMPH
別名：

Amp antibody; AMPH 1 antibody; AMPH antibody; AMPH_HUMAN antibody; AMPH1 antibody; Amphiphysin (Stiff-Man syndrome with breast cancer 128kD autoantigen) antibody; Amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen) antibody; Amphiphysin antibody; Amphiphysin I antibody; CG8604 antibody; Damp antibody; dAmph antibody; Dmel\CG8604 antibody; HGNC:471 antibody; MGC49429 antibody; Stiff man syndrome with breast cancer 128kD autoantigen antibody; Stiff man syndrome with breast cancer 128kDa autoantigen antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human Amphiphysin I.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.
基因功能參考文獻：
1. The data show that the dynamin-amphiphysin helices are rearranged to form clusters upon GTP hydrolysis and membrane constriction occurs at protein-uncoated regions flanking the clusters. PMID: 29357276
2. We show that AMPH-1/BIN1 binds to nesprin and actin, as well as to the microtubule-binding protein CLIP170 in both species. We propose that BIN1 has a direct and evolutionarily conserved role in nuclear positioning, altered in myopathies. PMID: 26506308
3. It is a nerve protein and its autoantibody causes paraneoplastic neurological syndromes. PMID: 25087559
4. AMPH1 protein level is reduced in transgenic mouse brain proteins. in the brainstem of nontransgenic and terminally ill JNPL3 transgenic mice. PMID: 22975846
5. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome PMID: 22331304
6. structure-based approach to prediction of peptide-binding behavior of SH3 domain of amphiphysin-1: statistical modeling PMID: 19669081
7. investigation of binding affinities of decapeptide ligands with amphiphysin SH3 domain using QSAR models PMID: 20214647
8. Female patient with amphiphysin autoantibodies and siff leg syndrome due to small cell cancer of the lung. PMID: 16671079
9. Amphiphysin I (Amph I) is a minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase substrate. Amph I phosphorylation changes the recruitment of endophilin at the endocytic sites. PMID: 16733250
10. This study demonstrates that the analysis of the molecular interaction energy components between peptides and the SH3 domain can successfully characterize the binding interface. PMID: 18206907
11. Analyses of Gaussian distribution models showed that diversified properties contribute to the interactions between the SH3 domain and of amphiphysin and peptides. PMID: 18814309
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亞細胞定位：

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
組織特異性：

Neurons, certain endocrine cell types and spermatocytes.
數據庫鏈接：

HGNC: 471

OMIM: 600418

KEGG: hsa:273

STRING: 9606.ENSP00000348602

UniGene: Hs.592182

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