ALKBH4 Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ALKBH4 Polyclonal antibody
Uniprot No.：

Q9NXW9
基因名：

ALKBH4
別名：

2010004B12Rik antibody; ABH4 antibody; Abj4 antibody; AlkB; alkylation repair homolog 4 (E. coli) antibody; ALKB4_HUMAN antibody; Alkbh4 antibody; Alkylated DNA repair protein alkB homolog 4 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 antibody; FLJ20013 antibody; Probable alpha-ketoglutarate dependent dioxygenase ABH4 antibody; RGD1308608 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 protein (1-115AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ALKBH4 Antibody (CSB-PA885759LA01HU)，的標記方式是Non-conjugated。對于ALKBH4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA885759LB01HU	ALKBH4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA885759LC01HU	ALKBH4 Antibody, FITC conjugated
Biotin	CSB-PA885759LD01HU	ALKBH4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:2000-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
基因功能參考文獻：
1. ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction. PMID: 23673617
2. The regions mediating binding to ALKBH4 comprised domains previously reported to be involved in interaction with DNA or chromatin. PMID: 23145062
3. ALKBH4 represents an active Fe(II)/2OG-dependent decarboxylase and suggest that the cysteine cluster is involved in processes other than Fe co-ordination. PMID: 21166655
亞細胞定位：

Cytoplasm. Nucleus. Nucleus, nucleolus. Midbody.
蛋白家族：

AlkB family
組織特異性：

Widely expressed, with highest expression in pancreas, ovary and spleen.
數據庫鏈接：

HGNC: 21900

OMIM: 613302

KEGG: hsa:54784

STRING: 9606.ENSP00000292566

UniGene: Hs.658598

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