Rat Interleukin 1β,IL-1β ELISA Kit

Rat Interleukin 1β,IL-1β ELISA Kit

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中文名稱：

大鼠白介素1β (IL-1β)酶聯(lián)免疫試劑盒
貨號(hào)：

CSB-E08055r-IS
規(guī)格：

96T/48T
價(jià)格：

￥3200/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star? Award in the ELISA category

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產(chǎn)品描述：

大鼠白介素1β (IL-1β)酶聯(lián)免疫試劑盒（CSB-E08055r-IS）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的IL1B含量。IL1B 是重要的細(xì)胞因子。在炎癥反應(yīng)等生理病理過程中發(fā)揮關(guān)鍵作用。研究發(fā)現(xiàn)它可激活下游炎癥信號(hào)通路，誘導(dǎo)多種炎癥介質(zhì)產(chǎn)生。針對(duì) IL1B 研發(fā)藥物，干預(yù)其作用機(jī)制，有望為炎癥相關(guān)疾病如類風(fēng)濕關(guān)節(jié)炎等治療提供新策略。試劑盒檢測(cè)范圍為31.25 pg/mL-2000 pg/mL，靈敏度為15.6 pg/mL。常用于評(píng)估感染性疾病、自身免疫病及神經(jīng)退行性病變等研究模型；廣泛用于炎癥機(jī)制研究、藥物抗炎效果評(píng)價(jià)、免疫調(diào)控實(shí)驗(yàn)及動(dòng)物疾病模型構(gòu)建，特別適用于腦、肝臟等組織勻漿中細(xì)胞因子釋放的動(dòng)態(tài)監(jiān)測(cè)。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
別名：

Il1bInterleukin-1 beta ELISA kit; IL-1 beta ELISA kit
縮寫：

IL1B
Uniprot No.：

Q63264
種屬：

Rattus norvegicus (Rat)
樣本類型：

serum, plasma, tissue homogenates
檢測(cè)范圍：

31.25 pg/mL-2000 pg/mL
靈敏度：

15.6 pg/mL
反應(yīng)時(shí)間：

1-5h
樣本體積：

50-100ul
檢測(cè)波長(zhǎng)：

450 nm
研究領(lǐng)域：

Immunology
測(cè)定原理：

quantitative
測(cè)定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of rat IL-1β in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

	Sample	Serum(n=4)
1:1	Average %	91
	Range %	91-105
1:2	Average %	102
	Range %	95-109
1:4	Average %	99
	Range %	92-105
1:8	Average %	93
	Range %	86-98

回收率：

標(biāo)準(zhǔn)曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml

OD1

OD2

Average

Corrected

2000

2.826

2.634

2.730

2.569

1000

2.045

1.967

2.006

1.845

500

1.349

1.328

1.339

1.177

250

0.818

0.829

0.824

0.662

125

0.474

0.491

0.482

0.321

62.5

0.344

0.353

0.349

0.187

31.25

0.238

0.244

0.241

0.080

0.157

0.165

0.161

數(shù)據(jù)處理：

ELISA操作視頻及標(biāo)曲繪制軟件下載
貨期：

3-5 working days

AA Saati,Brain Sciences,2025

功能：

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.
亞細(xì)胞定位：

Cytoplasm, cytosol. Lysosome. Secreted, extracellular exosome. Secreted.
蛋白家族：

IL-1 family
數(shù)據(jù)庫(kù)鏈接：

STRING: 10116.ENSRNOP00000006308

UniGene: Rn.9869

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.