Mouse amyloid beta peptide 1-42,Aβ1-42 ELISA Kit

Mouse amyloid beta peptide 1-42,Aβ1-42 ELISA Kit

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中文名稱：

小鼠β淀粉樣蛋白1-42(Aβ1-42)酶聯免疫試劑盒
貨號：

CSB-E10787m
規格：

96T/48T
價格：

￥3800/￥2500
促銷：
其他：

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產品描述：

小鼠β淀粉樣蛋白1-42(Aβ1-42)酶聯免疫試劑盒（CSB-E10787m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的Aβ1-42含量。Aβ1-42是重要的阿爾茨海默病相關靶點。在患者腦內該蛋白異常聚集形成淀粉樣斑塊，破壞神經細胞功能與結構。研究聚焦其產生、聚集過程及與神經毒性的關聯，旨在通過抑制生成、促進清除等機制來改善病情、研發治療藥物。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，適用于阿爾茨海默病小鼠模型構建、Aβ病理機制研究、藥物干預效果評估等實驗場景，為神經科學領域提供可靠的檢測工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

Amyloid beta 42(ABeta 42),amyloid beta peptide 1-42,Aβ1-42,amyloid βpeptide 1-42
縮寫：

Aβ1-42
種屬：

Mus musculus (Mouse)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

15.6 pg/mL-1000 pg/mL
靈敏度：

3.9 pg/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Neuroscience
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of mouse Aβ1-42 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	92
	Range %	88-99
1:2	Average %	95
	Range %	85-105
1:4	Average %	96
	Range %	90-105
1:8	Average %	93
	Range %	86-100

回收率：

The recovery of mouse Aβ1-42 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	95	90-100
EDTA plasma (n=4)	93	85-96

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average	Corrected
1000	2.490	2.451	2.471	2.337
500	2.049	1.985	2.017	1.883
250	1.357	1.385	1.371	1.237
125	0.866	0.837	0.852	0.718
62.5	0.517	0.524	0.521	0.387
31.2	0.347	0.355	0.351	0.217
15.6	0.244	0.228	0.236	0.102
0	0.135	0.132	0.134

數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer's disease by activating the Wnt/β-catenin signaling L Zhu, T Zhou, L Wu, X Zhu, L Chen, M Zhang,Scientific Reports,2025
Transcranial photobiomodulation induced frequency-specific dual-pathway glial activation for neurovascular protection vs amyloid clearance in Alzheimer's disease T Li, B Zhang, Z Chen, L Xu, S Yang, H Shen, X Wei,research square,2025
Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5?×?FAD mice H Chen, F Guo, Y Zhao, W Liu, B Chen,Frontiers in Aging Neuroscience,2025
A Novel Missense Variant in SORBS2 Is Causative With Familial Alzheimer's Disease Q Wang, S Wang, S Cao, Q Wang, Y Wei,CNS Neuroscience & Therapeutics,2025
Ultrasound Stimulation Modulates Microglia M1/M2 Polarization and Affects Hippocampal Proteomic Changes in a Mouse Model of Alzheimer's Disease X Lu, W Sun, L Leng, Y Yang, S Gong,Immunity, Inflammation and Disease,2024
Inhibition of Amyloid-β (Aβ)-Induced Cognitive Impairment and Neuroinflammation in CHI3L1 Knockout Mice through Downregulation of ERK-PTX3 Pathway HJ Ham,International journal of molecular sciences,2024
Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease Y Guo,In vitro cellular & developmental biology. Animal,2023
Bioengineered microglia-targeted exosomes facilitate Aβ clearance via enhancing activity of microglial lysosome for promoting cognitive recovery in Alzheimer's disease Y Hao,Biomaterials Advances,2023
Yuanzhi Powder Facilitated the Aβ Clearance in App/Ps1 Mice: Target to the Drainage of Glymphatic System and Meningeal Lymphatic Vessels J Li,Available at SSRN 4528275,2023
Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer's disease W Li,BMC medicine,2023
The multifactorial role of vanillin in amelioration of aluminium chloride and D-galactose induced Alzheimer's disease in mice A Anand,European journal of pharmacology,2023
TNIP2 Inhibits Amyloidogenesis by Regulating the 3'UTR of BACE1 L Wang,Neuroscience letters,2023
TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: an in vitro study L Chen,Neuroscience letters,2023
Protective Effect of Biobran/MGN-3 against Sporadic Alzheimer's Disease Mouse Model: Possible Role of Oxidative Stress and Apoptotic Pathways MH Ghoneu,Oxidative Medicine and Cellular Longevity,2021
Suan-Zao-Ren Decoction ameliorates synaptic plasticity through inhibition of the Aβ deposition and JAK2/STAT3 signaling pathway in AD model of APP/PS1 transgenic mice Qing-Hua Lon,BMC Chinese Medicine,2021
Astaxanthin Improved the Cognitive Deficits in APP/PS1 Transgenic Mice Via Selective Activation of mTOR C Huang,Journal of Neuroimmune Pharmacology,2020
Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: Involvements of AMPK/SIRT1 pathway and amyloid-tau-neuroinflammation axis R Hao,Food and Chemical Toxicology,2020
Long-term consumption of alcohol exacerbates neural lesions by destroying the functional integrity of the blood-brain barrier Wei J, et al,Drug and Chemical Toxicology,2019
Nanoformulated ellagic acid ameliorates pentylenetetrazol-induced experimental epileptic seizures by modulating oxidative stress, inflammatory cytokines and apoptosis in the brains of male mice El-Missiry M A, et al,Metabolic Brain Disease,2019
Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice Ham H J, et al,Translational Neurodegeneration,2019
Albiflorin ameliorates memory deficits in APP/PS1 transgenic mice via ameliorating mitochondrial dysfunction Xu YJ,Brain Research,2019
PROTEASOME INHIBITORS Kim, Kyung Bo,/,2019
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation Zhu BL, et al,Brain,2019
K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression Ji Yeon Choi, .et al,Journal of Neuroinflammation,2018
Knockdown of BACE1 Wenting Zhang.et al,EXP THER MED,2018
Stereoisomers of Schisandrin B Are Potent ATP Competitive GSK-3β Inhibitors with Neuroprotective Effects against Alzheimer’s Disease: Stereochemistry and Biological Activity Xiao-Long Hu.et al,ACS CHEM NEUROSCI,2018
Ligustilide ameliorates memory deficiency in APP/PS1 transgenic mice via restoring mitochondrial dysfunction Yi-Jun Xu.et al,/,2018
The Mechanisms of Bushen-Yizhi Formula as a Therapeutic Agent against Alzheimer\'s Disease Cai H.et al,Sci Rep,2018
Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice Haobin Cai.et al,learning and memory,2017
Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer\'s Disease Kuang X.et al,Front Aging Neurosci,2017
Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid in Counteracting LPS-Induced Neuroinflammation via Modulation of miRNA-155 Sayed AS.et al,Mol Neurobiol,2017
(E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates LPS-Mediated Memory Impairment by Inhibition of STAT3 Pathway Choi JY.et al,Neuromolecular Med.,2017
KRICT-9 inhibits neuroinflammation, amyloidogenesis and memory loss in Alzheimer’s disease models Lee DY.et al,Oncotarget.,2017
Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice Neuroscience.et al,Neuroscience,2017
The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice Tian F.et al,PLoS One.,2017
Possible role of metal ionophore against zinc induced cognitive dysfunction in D-galactose senescent mice Kanchan Bharti.et al,Biometals.,2016
Lactobacillus plantarum CCFM639 can prevent aluminium-induced neural injuries and abnormal behaviour in mice Leilei Yu.et al,Journal of Functional Foods,2017
Possible role of metal ionophore against zinc induced cognitive dysfunction in D-galactose senescent mice. Bharti K.et al,Biometals.,2016
Antidiabetic drugs restore abnormal transport of amyloid-ß across the blood-brain barrier and memory impairment in db/db mice Chen F. et al,Neuropharmacology,2015

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最新研究進展：

Aβ1-42是β淀粉樣蛋白（Aβ）家族的一員，它是阿爾茨海默病（AD）病理學的主要成分。最近的研究表明，Aβ1-42的積聚是導致AD的主要因素之一。已經發現許多抗Aβ1-42藥物，如免疫療法和β-淀粉樣蛋白藥物，這些藥物能夠清除Aβ1-42，并恢復AD患者的認知能力。此外，一些研究還發現，Aβ1-42可能是癲癇的重要病理因素，這為癲癇治療提供了新的思路。

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.