USP33
USP33，即泛素特異性蛋白酶33，別名Ubiquitin-specificproteases33。它是由人類基因組中的USP33基因編碼的蛋白酶，屬于去泛素化酶家族的重要成員。USP33在細胞內主要通過對底物蛋白的去泛素化來阻止蛋白酶體降解，進而調節細胞內多種生命活動，包括信號通路、自噬、中心體擴增以及腫瘤發生發展。其作用機制涉及與特定蛋白質相互作用，通過去除泛素鏈來調節這些蛋白質的穩定性和活性，如通過deubiquitinationofthecentriolarproteinCP110調節中心體生物合成。USP33在維持細胞內蛋白穩態、細胞周期調控、基因組穩定性以及腫瘤發生中發揮重要作用。USP33的異常表達與多種疾病相關，尤其是在腫瘤的預防、治療及預后中可能提供新的治療方向。
熱銷產品
USP33 Antibody (CSB-PA840583LA01HU)
驗證數據
Western Blot
Positive WB detected in: Hela whole cell lysate
All lanes: USP33 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 107, 104, 94 kDa
Observed band size: 107 kDa
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA840583LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA840583LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
USP33 Antibodies
USP33 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA025724GA01HU | USP33 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA840583LA01HU | USP33 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA840583LB01HU | USP33 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA840583LC01HU | USP33 Antibody, FITC conjugated | Human |
USP33 Proteins
USP33 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP840583HU CSB-EP840583HU CSB-BP840583HU CSB-MP840583HU CSB-EP840583HU-B |
Recombinant Human Ubiquitin carboxyl-terminal hydrolase 33 (USP33), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
