TRIM21
TRIM21，即三結構域蛋白21，別名Ro52、Ssa1，屬于三結構域蛋白家族成員之一，主要在細胞內發揮作用。
TRIM21的作用機制涉及其作為E3泛素連接酶的功能，依賴于E2酶如UBE2D1、UBE2D2、UBE2E1和UBE2E2，與UBE2D2形成泛素連接酶復合物，泛素化USP4、IKBKB及其自身，還與基于cullin-RING的SCF E3連接酶復合物相關，介導CDKN1B泛素化。TRIM21是細胞內抗體效應器，在細胞內抗體介導的蛋白降解途徑中發揮作用，識別Fc結構域并結合抗體標記的非包膜病毒，通過自泛素化或泛素化輔助因子，將病毒引導至蛋白酶體進行降解。此外，TRIM21還參與固有免疫反應，通過影響細胞內PRR介導的信號傳導，積極或消極地調節抗病毒反應。
TRIM21的功能異常與多種自身免疫性疾病相關，如系統性紅斑狼瘡等。
熱銷產品
Recombinant Human E3 ubiquitin-protein ligase TRIM21 (TRIM21) (CSB-BP024457HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TRIM21 Antibody (CSB-PA024457LA01HU)
驗證數據
Western Blot
Positive WB detected in: A549 whole cell lysate
All lanes: TRIM21 antibody at 2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 55, 46 kDa
Observed band size: 55 kDa
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA024457LA01HU at dilution of 1:100
TRIM21 Antibodies
TRIM21 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA024457GA01HU | TRIM21 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA173569 | TRIM21 Antibody | Human | ELISA,IHC |
| CSB-PA548244 | TRIM21 Antibody | Human | ELISA,WB |
| CSB-PA024457LA01HU | TRIM21 Antibody | Human | ELISA, WB, IHC |
| CSB-PA024457LB01HU | TRIM21 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA024457LC01HU | TRIM21 Antibody, FITC conjugated | Human | |
| CSB-PA024457LD01HU | TRIM21 Antibody, Biotin conjugated | Human | ELISA |
TRIM21 for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA733816LA01MO | Trim21 Antibody | Mouse | ELISA |
| CSB-PA733816LB01MO | Trim21 Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA733816LD01MO | Trim21 Antibody, Biotin conjugated | Mouse | ELISA |
TRIM21 Proteins
TRIM21 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP024457HU | Recombinant Human E3 ubiquitin-protein ligase TRIM21 (TRIM21) | Yeast |
| CSB-EP024457HU | Recombinant Human E3 ubiquitin-protein ligase TRIM21 (TRIM21) | E.coli |
| CSB-MP024457HU CSB-EP024457HU-B |
Recombinant Human E3 ubiquitin-protein ligase TRIM21 (TRIM21) | Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP024457HU | Recombinant Human E3 ubiquitin-protein ligase TRIM21 (TRIM21) | Baculovirus |
| CSB-EP024457HUc7 | Recombinant Human E3 ubiquitin-protein ligase TRIM21 (TRIM21) | E.coli |
TRIM21 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP733816MO CSB-MP733816MO CSB-EP733816MO-B |
Recombinant Mouse E3 ubiquitin-protein ligase TRIM21 (Trim21) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP733816MO | Recombinant Mouse E3 ubiquitin-protein ligase TRIM21 (Trim21) | E.coli |
| CSB-EP733816MOa0 | Recombinant Mouse E3 ubiquitin-protein ligase TRIM21 (Trim21) | E.coli |
TRIM21 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP768741BO CSB-EP768741BO CSB-BP768741BO CSB-MP768741BO CSB-EP768741BO-B |
Recombinant Bovine E3 ubiquitin-protein ligase TRIM21 (TRIM21) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
