TRAF2
TNF receptor-associated factor 2 is a protein in humans that is encoded by TRAF2 gene. Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
TRAF2 Antibodies
TRAF2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004323 | TRAF2 Antibody | Human | WB, IHC, ELISA |
| CSB-PA034758 | TRAF2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA024147LA01HU | TRAF2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA024147LB01HU | TRAF2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA024147LC01HU | TRAF2 Antibody, FITC conjugated | Human | |
| CSB-PA024147LD01HU | TRAF2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA786226A0HU | TRAF2 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, FC, IP |
TRAF2 Proteins
TRAF2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP024147MO CSB-EP024147MO CSB-BP024147MO CSB-MP024147MO CSB-EP024147MO-B |
Recombinant Mouse TNF receptor-associated factor 2 (Traf2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TRAF2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP024147HU CSB-EP024147HU CSB-BP024147HU CSB-MP024147HU CSB-EP024147HU-B |
Recombinant Human TNF receptor-associated factor 2 (TRAF2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP024147HUa0 | Recombinant Human TNF receptor-associated factor 2 (TRAF2) | E.coli |
