TNFRSF1B

TNFRSF1B（TNF receptor superfamily member 1b）為TNF受體超家族成員，也稱為TNFR2，主要表達在腫瘤微環境中的Treg細胞和多種腫瘤細胞中（如卵巢癌和腸癌）。TNFR2與受體TNF結合后，通過激活典型和非典型的NF-kB通路來控制細胞的生存和增殖。大量研究顯示，TNFR2抑制劑能夠特異性抑制在腫瘤微環境中高表達TNFR2的Tregs的功能，同時特異性殺傷腫瘤細胞，用于抗腫瘤治療；而TNFR2激活劑則可以激活Tregs細胞，抑制效應性T細胞（Teff），進而下調免疫反應，可以用于自身免疫疾病治療。隨著對于新靶點的不斷深入挖掘，TNFR2的重要性日漸受到關。TNFR2已經成為免疫逃逸、腫瘤生長以及檢查點阻斷抵抗性的潛在誘因。TNFR2抑制劑抗體則能夠抑制腫瘤相關Tregs的增殖和功能。

Recombinant Human TNFRSF1B 活性蛋白實驗驗證數據

High Purity Validated
by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized TNF-α (CSB-YP023955HU) at 5 μg/ml can bind human TNFR2, the EC₅₀ of human TNFR2 protein is 1.162-1.481 ng/ml.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized LTA (CSB-MP013218HU) at 5 μg/ml can bind human TNFRSF1B, the EC₅₀ is 1.632-2.699 ng/ml.

TNFRSF1B Antibody

TNFRSF1B Protein

TNFRSF1B ELISA Kit

TNFRSF1B Antibodies

TNFRSF1B for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA023978GA01HU	TNFRSF1B Antibody	Human	ELISA,WB,IHC
CSB-PA949730	TNFRSF1B Antibody	Human,Mouse,Rat	ELISA,WB,IF
CSB-PA004309	TNFRSF1B Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA229503	TNFRSF1B Antibody	Human	ELISA,WB,IHC
CSB-PA234429	TNFRSF1B Antibody	Human	ELISA,WB

TNFRSF1B Proteins

TNFRSF1B Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP023978MO1 CSB-EP023978MO1 CSB-BP023978MO1 CSB-MP023978MO1 CSB-EP023978MO1-B	Recombinant Mouse Tumor necrosis factor receptor superfamily member 1B (Tnfrsf1b), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023978MO	Recombinant Mouse Tumor necrosis factor receptor superfamily member 1B (Tnfrsf1b)	in vitro E.coli expression system

TNFRSF1B Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP800353RA CSB-EP800353RA CSB-BP800353RA CSB-MP800353RA CSB-EP800353RA-B	Recombinant Rat Tumor necrosis factor receptor superfamily member 1B (Tnfrsf1b), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNFRSF1B Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-EP023978HU1	Recombinant Human Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), partial	E.coli
CSB-AP002371HU	Recombinant Human Tumor necrosis factor receptor superfamily member 1B protein (TNFRSF1B), partial (Active)	E.Coli
CSB-CF023978HU	Recombinant Human Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)	in vitro E.coli expression system
CSB-YP023978HU2	Recombinant Human Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), partial	Yeast
CSB-AP004891HU	Recombinant Human Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), partial (Active)	Mammalian cell
CSB-MP023978HU2	Recombinant Human Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), partial (Active)	Mammalian cell