Rat Tumor necrosis factor soluble receptor Ⅱ,TNFsR-Ⅱ ELISA KIT
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中文名稱：大鼠腫瘤壞死因子可溶性受體Ⅱ(TNFsR-Ⅱ)酶聯免疫試劑盒
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貨號：CSB-E07380r
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規格：96T/48T
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價格：￥3600/￥2500
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其他：
產品詳情
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產品描述：大鼠腫瘤壞死因子可溶性受體Ⅱ(TNFsR-Ⅱ)酶聯免疫試劑盒（CSB-E07380r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的TNFsR2含量。TNFsR2 是重要靶點。TNF 家族參與多種生理病理過程，TNFsR2 作為其受體之一，在免疫調節、細胞存活與凋亡等方面發揮作用。研究聚焦其與配體結合機制，以及在疾病如炎癥、腫瘤中的信號傳導通路，旨在為相關疾病治療提供新思路。試劑盒檢測范圍為0.625 ng/mL-40 ng/mL，適用于科研實驗中動態監測動物模型（如關節炎、膿毒癥等）的炎癥進程、評估藥物干預對受體表達水平的影響，或探究TNF信號通路相關疾病的分子機制。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：Tnfrsf1b ELISA Kit; Tnfr2 ELISA Kit; Tumor necrosis factor receptor superfamily member 1B ELISA Kit; Tumor necrosis factor receptor 2 ELISA Kit; TNF-R2 ELISA Kit; Tumor necrosis factor receptor type II ELISA Kit; TNF-RII ELISA Kit; TNFR-II ELISA Kit; p75 ELISA Kit; p80 TNF-alpha receptor ELISA Kit; CD antigen CD120b ELISA Kit
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縮寫：TNFsR-
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Uniprot No.：
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種屬：Rattus norvegicus (Rat)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：0.625 ng/mL-40 ng/mL
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靈敏度：0.156 ng/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Others
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of rat TNFsR-II in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 91 Range % 87-94 1:2 Average % 97 Range % 92-101 1:4 Average % 90 Range % 87-98 1:8 Average % 92 Range % 85-95 -
回收率：
The recovery of rat TNFsR-II spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 93 88-96 EDTA plasma (n=4) 98 95-102 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
ng/ml OD1 OD2 Average Corrected 40 2.827 2.899 2.863 2.732 20 2.222 2.323 2.273 2.142 10 1.373 1.412 1.393 1.262 5 0.816 0.866 0.841 0.710 2.5 0.531 0.545 0.538 0.407 1.25 0.315 0.323 0.319 0.188 0.625 0.226 0.241 0.234 0.103 0 0.126 0.135 0.131 -
數據處理：
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貨期：3-5 working days
產品評價
相關產品
靶點詳情
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功能：Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
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基因功能參考文獻：
- results suggested that PTE may promote BMSC proliferation and osteogenic differentiation via a mechanism associated with the regulation of Let-7f-5p and the TNFR2/PI3K/AKT signaling pathway. PMID: 29975930
- Curcumin decreased TNFR2 and increased TRAF2 to decrease the apoptotic pathway in ureteral obstruction rats. PMID: 26732833
- The IL-17RD.TNFR2 complex in activation of NF-kappaB may explain the role of TNFR2 in inflammatory diseases including nephritis. PMID: 25378394
- the microglial TNF-alpha p55 pathway played a more important role than the TNF-alpha p75 pathway in the pathogenesis of peripheral nerve injury pain. PMID: 22652595
- study of TNF-alpha and TnfrR2 protein synthesis and expression patterns in sciatic nerve of controls and rats under systemic challenge with lipopolysaccharide. PMID: 17873366
- In human biopsies and in rat kidney allografts on day 6 with acute allograft rejection, significantly elevated expression of TNFR2 was observed. PMID: 19298452
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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數據庫鏈接：
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