TMEM176B
TMEM176B，全稱Transmembrane Protein 176B，是一種跨膜蛋白，也被稱為LR8或MS4B2。研究表明，TMEM176B在多種癌癥中高表達，且與患者較短的無病生存期相關。在卵巢癌中，TMEM176B通過抑制Wnt/β-catenin信號通路的激活來抑制EMT，進而阻礙卵巢癌的進展。此外，TMEM176B還在其他疾病中發(fā)揮作用，例如在家族性tau蛋白病中，TMEM176B的表達水平降低，這表明TMEM176B可能參與tau蛋白病相關的免疫反應。基于這些發(fā)現(xiàn)，TMEM176B有望成為多種癌癥的診斷和預后評估的生物標志物，以及治療的新靶點。目前，針對TMEM176B的藥物研發(fā)尚處于起步階段，未來需要更多的研究來探索其潛在的應用價值。
熱銷產(chǎn)品
TMEM176B Antibody (CSB-PA023758LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: THP-1 whole cell lysate(30μg), SY5Y whole cell lysate(30μg), Hela whole cell lysate(30μg), K562 whole cell lysate(30μg)
All lanes: TMEM176B antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 30,26 kDa
Observed band size: 30 kDa
Exposure time：120s
Immunofluorescence staining of Hela cell with CSB-PA023758LA01HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and and permeated by 0.2% TritonX-100 for 15 min. Then 10% normal goat serum to block non-specific protein-protein interactions . The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunofluorescence staining of Hela cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
TMEM176B Antibodies
TMEM176B for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA023758GA01HU | TMEM176B Antibody | Human | ELISA,WB |
| CSB-PA023758LA01HU | TMEM176B Antibody | Human | ELISA, WB, IF |
| CSB-PA023758LC01HU | TMEM176B Antibody, FITC conjugated | Human | |
| CSB-PA023758LB01HU | TMEM176B Antibody, HRP conjugated | Human | ELISA |
TMEM176B Proteins
TMEM176B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023758HU1 CSB-EP023758HU1 CSB-BP023758HU1 CSB-MP023758HU1 CSB-EP023758HU1-B |
Recombinant Human Transmembrane protein 176B (TMEM176B), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023758HU | Recombinant Human Transmembrane protein 176B (TMEM176B) | in vitro E.coli expression system |
