TFEB
TFEB，即轉(zhuǎn)錄因子EB，別名TcelltranscriptionfactorEB、TCFEB。它是由人類TFEB基因編碼的一種轉(zhuǎn)錄因子，屬于堿性螺旋-環(huán)-螺旋亮氨酸拉鏈（bHLH-Zip）結(jié)構(gòu)的轉(zhuǎn)錄因子家族。TFEB主要在多種細(xì)胞過(guò)程中發(fā)揮作用，尤其是在自噬-溶酶體生物發(fā)生、細(xì)胞能量穩(wěn)態(tài)和代謝過(guò)程中。其作用機(jī)制涉及通過(guò)磷酸化等翻譯后修飾（PTMs）控制其亞細(xì)胞定位，從而在營(yíng)養(yǎng)應(yīng)激、內(nèi)質(zhì)網(wǎng)應(yīng)激、感染、線粒體損傷和炎癥等情況下，從細(xì)胞質(zhì)轉(zhuǎn)移到細(xì)胞核，激活目標(biāo)基因的表達(dá)。TFEB是自噬/溶酶體-核信號(hào)通路的中樞調(diào)控因子，參與能量穩(wěn)態(tài)、應(yīng)激反應(yīng)、代謝、自噬和溶酶體生物發(fā)生等信號(hào)通路。TFEB的活性受多種上游因素的控制，包括營(yíng)養(yǎng)物質(zhì)的利用率和脅迫。TFEB的功能異常與多種疾病相關(guān)，如溶酶體儲(chǔ)存障礙、神經(jīng)退行性疾病、癌癥和代謝紊亂等。TFEB被認(rèn)為是臨床和再生應(yīng)用的一個(gè)新的治療靶點(diǎn)。
熱銷產(chǎn)品
TFEB Antibody (CSB-PA023429ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Transcription factor EB antibody at 3μg/ml
Lane 1: Jurkat whole cell lysate
Lane 2: Mouse brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 53, 44 kDa
Observed band size: 53 kDa
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA023429ESR1HU at dilution of 1:100
TFEB Antibodies
TFEB for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023429GA01HU | TFEB Antibody | Human,Mouse,Rat | ELISA,WB,IP,IHC,IF |
| CSB-PA023429ESR1HU | TFEB Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA023429ESR2HU | TFEB Antibody | Human | ELISA, IHC |
| CSB-PA060145 | TFEB Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA023429EA01HU | TFEB Antibody | Human, Rat | ELISA, WB, IHC, IF |
| CSB-PA023429EC01HU | TFEB Antibody, FITC conjugated | Human | |
| CSB-PA023429ED01HU | TFEB Antibody, Biotin conjugated | Human | ELISA |
TFEB Proteins
TFEB Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-BP023429HU CSB-MP023429HU CSB-EP023429HU-B |
Recombinant Human Transcription factor EB (TFEB) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP023429HU | Recombinant Human Transcription factor EB (TFEB) | E.coli |
TFEB Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023429MO CSB-EP023429MO CSB-BP023429MO CSB-MP023429MO CSB-EP023429MO-B |
Recombinant Mouse Transcription factor EB (Tfeb) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
