TCF4
TCF4，即T細胞因子4，別名ITF2、E2-2、SEF-1。它是一種含有高遷移率族蛋白結(jié)構(gòu)域的核轉(zhuǎn)錄因子，主要來源于哺乳動物的基因組。TCF4的作用機制主要是通過其高遷移率族蛋白結(jié)構(gòu)域(HMG)結(jié)合DNA，與β-catenin形成轉(zhuǎn)錄復(fù)合體，調(diào)控Wnt信號通路中的靶基因表達。在生物學(xué)意義上，TCF4在細胞增殖、分化、遷移、極性化和凋亡中發(fā)揮重要作用，尤其在神經(jīng)發(fā)育、腫瘤發(fā)生發(fā)展以及精神疾病中具有重要功能。TCF4的異常表達與多種疾病相關(guān)，包括精神分裂癥、Pitt-Hopkins綜合征以及某些類型的癌癥。
熱銷產(chǎn)品
TCF4 Antibody (CSB-PA023302HA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue
All lanes: TCF4 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 72, 55, 49, 66, 65, 58, 68, 64, 70, 69, 63 kDa
Observed band size: 72 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA023302HA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA023302HA01HU at dilution of 1:100
TCF4 Antibodies
TCF4 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023302HA01HU | TCF4 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA023302HB01HU | TCF4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023302HC01HU | TCF4 Antibody, FITC conjugated | Human | |
| CSB-PA023302HD01HU | TCF4 Antibody, Biotin conjugated | Human | ELISA |
TCF4 Proteins
TCF4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023302HU CSB-EP023302HU CSB-BP023302HU CSB-MP023302HU CSB-EP023302HU-B |
Recombinant Human Transcription factor 4 (TCF4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
