SPA17
SPA17全稱為精子發(fā)生相關(guān)蛋白17，也被稱為SP17或CT37，最初在男性生殖細(xì)胞中被發(fā)現(xiàn)，主要參與精子形成及受精過程中的透明帶結(jié)合。SPA17在卵巢癌、肺癌、多發(fā)性骨髓瘤等多種惡性腫瘤中異常高表達，通過增強細(xì)胞遷移能力和促進血管生成參與腫瘤進展。其分子機制涉及調(diào)控細(xì)胞外基質(zhì)重塑相關(guān)蛋白水解酶活性，并與整合素信號網(wǎng)絡(luò)形成交互作用，可能影響腫瘤細(xì)胞對微環(huán)境的適應(yīng)性。目前針對SPA17的抗體藥物及多肽疫苗已進入臨床前研究階段，特別是在卵巢癌治療領(lǐng)域，利用其腫瘤特異性表達的免疫治療策略展現(xiàn)出潛力。有研究發(fā)現(xiàn)靶向SPA17的CAR-T細(xì)胞療法在動物實驗中成功抑制了腫瘤轉(zhuǎn)移，同時被證實與免疫逃逸相關(guān)，其阻斷劑可能成為聯(lián)合PD-1抑制劑的新型治療方案。
熱銷產(chǎn)品
Recombinant Human Sperm surface protein Sp17 (SPA17), partial (CSB-EP614892HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP121244h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SPA17.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP121244h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SPA17.
SPA17 Antibody (CSB-PA12124A0Rb)
驗證數(shù)據(jù)
IHC image of CSB-PA12124A0Rb diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA12124A0Rb diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
SPA17 Antibodies
SPA17 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA022451GA01HU | SPA17 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA12124A0Rb | SPA17 Antibody | Human | ELISA, IHC |
| CSB-PA12124C0Rb | SPA17 Antibody, FITC conjugated | Human |
SPA17 Proteins
SPA17 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP614892HU1 | Recombinant Human Sperm surface protein Sp17 (SPA17), partial | E.coli |
| CSB-YP614892HU CSB-EP614892HU CSB-BP614892HU CSB-MP614892HU CSB-EP614892HU-B |
Recombinant Human Sperm surface protein Sp17 (SPA17) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
