SMPD3
SMPD3，全稱(chēng)為鞘磷脂磷酸二酯酶3，是一種在細(xì)胞膜上發(fā)揮重要作用的酶。它有多種別名，如中性鞘磷脂酶II。SMPD3的主要功能是參與鞘磷脂的代謝，鞘磷脂是一種重要的脂質(zhì)分子，與細(xì)胞膜的穩(wěn)定性和信號(hào)傳導(dǎo)有關(guān)。在肝臟疾病中，如代謝功能障礙相關(guān)脂肪性肝炎（MASH），SMPD3的表達(dá)和活性異常可能導(dǎo)致脂質(zhì)代謝紊亂，進(jìn)而引發(fā)炎癥和纖維化。近年來(lái)，研究人員發(fā)現(xiàn)靶向SMPD3可能成為治療MASH的新策略，目前已有針對(duì)SMPD3的雙靶點(diǎn)藥物進(jìn)入研發(fā)階段，顯示出良好的治療前景。
熱銷(xiāo)產(chǎn)品
Recombinant Human Sphingomyelin phosphodiesterase 3 (SMPD3), partial (CSB-EP878920HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SMPD3 Antibody (CSB-PA878920LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA878920LA01HU at dilution of 1:100
Immunoprecipitating SMPD3 in mouse brain whole cell lysate
Lane 1: Rabbit control IgG (1μg) instead of CSB-PA878920LA01HU in mouse brain whole cell lysate.
For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA878920LA01HU (6μg) + Mouse brain whole cell lysate (500μg)
Lane 3: Mouse brain whole cell lysate (10μg)
SMPD3 Antibodies
SMPD3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA878920LA01HU | SMPD3 Antibody | Human, Mouse | ELISA, IHC, IP |
| CSB-PA878920LB01HU | SMPD3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA878920LC01HU | SMPD3 Antibody, FITC conjugated | Human | |
| CSB-PA878920LD01HU | SMPD3 Antibody, Biotin conjugated | Human | ELISA |
SMPD3 Proteins
SMPD3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP878920HU CSB-EP878920HU CSB-BP878920HU CSB-MP878920HU CSB-EP878920HU-B |
Recombinant Human Sphingomyelin phosphodiesterase 3 (SMPD3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP878920HU1 | Recombinant Human Sphingomyelin phosphodiesterase 3 (SMPD3), partial | E.coli |
