SCAP
SCAP is a protein in humans that is encoded by SCAP gene. Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).
SCAP Antibodies
SCAP for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA020758GA01HU | SCAP Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA277938 | SCAP Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA180985 | SCAP Antibody | Human,Mouse,Rat | ELISA,IHC |
SCAP Proteins
SCAP Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP020758RA CSB-EP020758RA CSB-BP020758RA CSB-MP020758RA CSB-EP020758RA-B |
Recombinant Rat Sterol regulatory element-binding protein cleavage-activating protein (Scap), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SCAP Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP020758BO CSB-EP020758BO CSB-BP020758BO CSB-MP020758BO CSB-EP020758BO-B |
Recombinant Bovine Sterol regulatory element-binding protein cleavage-activating protein (SCAP), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SCAP Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP020758DXU CSB-EP020758DXU CSB-BP020758DXU CSB-MP020758DXU CSB-EP020758DXU-B |
Recombinant Cricetulus griseus Sterol regulatory element-binding protein cleavage-activating protein (SCAP), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SCAP Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP020758XBE CSB-EP020758XBE CSB-BP020758XBE CSB-MP020758XBE CSB-EP020758XBE-B |
Recombinant Xenopus laevis Sterol regulatory element-binding protein cleavage-activating protein (scap), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SCAP Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP622510HU CSB-EP622510HU CSB-BP622510HU CSB-MP622510HU CSB-EP622510HU-B |
Recombinant Human Sterol regulatory element-binding protein cleavage-activating protein (SCAP), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SCAP Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP702805PI CSB-EP702805PI CSB-BP702805PI CSB-MP702805PI CSB-EP702805PI-B |
Recombinant Pig Sterol regulatory element-binding protein cleavage-activating protein (SCAP), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SCAP Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP756982MO CSB-EP756982MO CSB-BP756982MO CSB-MP756982MO CSB-EP756982MO-B |
Recombinant Mouse Sterol regulatory element-binding protein cleavage-activating protein (Scap), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
