RIPK4
RIPK4,全稱為Receptor-interacting serine/threonine-protein kinase 4,是一種參與細(xì)胞程序性死亡、炎癥反應(yīng)和免疫應(yīng)答等關(guān)鍵生物學(xué)過(guò)程的絲氨酸/蘇氨酸蛋白激酶。該蛋白在表皮、角質(zhì)形成細(xì)胞和某些免疫細(xì)胞中高表達(dá),主要通過(guò)NF-κB和MAPK信號(hào)通路參與皮膚發(fā)育、傷口愈合和先天免疫防御。RIPK4蛋白的表達(dá)水平與多種疾病的發(fā)生發(fā)展密切相關(guān),包括皮膚癌、卵巢癌、宮頸癌和結(jié)腸直腸癌等。近年來(lái),RIPK4蛋白已成為癌癥治療的一個(gè)吸引人的靶點(diǎn),多個(gè)針對(duì)RIPK4的藥物研發(fā)項(xiàng)目正在推進(jìn)中,其中不乏一些具有突破性進(jìn)展的項(xiàng)目。例如,維泰瑞隆公司申報(bào)的1類新藥SIR2501片獲得了臨床試驗(yàn)?zāi)驹S可,計(jì)劃用于治療肌萎縮側(cè)索硬化癥(ALS),即人們常說(shuō)的“漸凍癥”。此外,RIPK4蛋白還在自身免疫性疾病中發(fā)揮重要作用,例如銀屑病等。針對(duì)RIPK4蛋白的藥物研發(fā),有望為這些疾病患者帶來(lái)新的治療選擇。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA436282(RIPK4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA436282(RIPK4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
RIPK4 Antibodies
RIPK4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA436282 | RIPK4 Antibody | Human | ELISA,IHC |
| CSB-PA087089 | RIPK4 Antibody | Human | ELISA,IHC |
RIPK4 Proteins
RIPK4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP019738HU CSB-EP019738HU CSB-BP019738HU CSB-MP019738HU CSB-EP019738HU-B |
Recombinant Human Receptor-interacting serine/threonine-protein kinase 4 (RIPK4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |






