RIPK1
RIPK，即受體相互作用絲氨酸/蘇氨酸蛋白激酶1，別名RIP1。RIPK1是一種胞質蛋白激酶，能夠調節多種炎癥和細胞死亡途徑。它在腫瘤壞死因子受體1 (TNFR1) 信號通路中的作用已被廣泛研究，其激酶活性對調控過程至關重要。RIPK1可以參與形成多種信號復合體，如復合體I（TNF-RSC），通過泛素化修飾促進NF-κB激活和抑制其激酶活性，從而抑制胚胎發生和炎癥過程中RIPK1依賴的細胞死亡。RIPK1在生物學上的意義非常重大，它不僅參與細胞凋亡、壞死性凋亡（necroptosis）以及炎癥信號通路的調控，還涉及胚胎發育、造血系統發育以及免疫穩態的維持等多種重要生物學過程。RIPK1的功能異常與多種疾病有關，包括自身免疫缺陷、自身炎癥性疾病、漸凍癥、風濕性關節炎以及結腸炎等。靶向RIPK1的小分子藥物正在臨床試驗階段，用于治療這些疾病。此外，RIPK1的磷酸化、泛素化等翻譯后修飾對其活性的調節在生理和病理條件下均發揮關鍵作用。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
RIPK1 Antibody (CSB-PA618785LA01HU)
驗證數據
Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate, Hela whole cell lysate, K562 whole cell lysate, Jurkat whole cell lysate, 293 whole cell lysate, Rat liver tissue, Mouse heart tissue, Mouse kidney tissue
All lanes: RIPK1 antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 76, 71 kDa
Observed band size: 76 kDa
Immunofluorescence staining of HepG2 cells with CSB-PA618785LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
RIPK1 Antibodies
RIPK1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA019735GA01HU | RIPK1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA618785LA01HU | RIPK1 Antibody | Human, Rat, Mouse | ELISA, WB, IF |
| CSB-PA618785LB01HU | RIPK1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA618785LC01HU | RIPK1 Antibody, FITC conjugated | Human | |
| CSB-PA618785LD01HU | RIPK1 Antibody, Biotin conjugated | Human | ELISA |
RIPK1 for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA720181LA01MO | Ripk1 Antibody | Mouse, Human | ELISA, WB, IP |
| CSB-PA720181LB01MO | Ripk1 Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA720181LC01MO | Ripk1 Antibody, FITC conjugated | Mouse | |
| CSB-PA720181LD01MO | Ripk1 Antibody, Biotin conjugated | Mouse | ELISA |
RIPK1 Proteins
RIPK1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP618785HU CSB-EP618785HU CSB-BP618785HU CSB-MP618785HU CSB-EP618785HU-B |
Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP618785HU2 | Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 (RIPK1), partial | E.coli |
| CSB-BP618785HUc7 | Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) | Baculovirus |
RIPK1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP720181MO | Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 (Ripk1) | Yeast |
| CSB-EP720181MO | Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 (Ripk1) | E.coli |
| CSB-MP720181MO CSB-EP720181MO-B |
Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 (Ripk1) | Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP720181MOa2 | Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 (Ripk1) | E.coli |
RIPK1 Proteins for Mus musculus(Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-BP720181MO | Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 (Ripk1) | Baculovirus |
RIPK1 Proteins for Human respiratory syncytial virus A (strain A2)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-BP618785HU2 | Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 (RIPK1), partial | Baculovirus |
