RBMS1
RBMS1，即RNA結(jié)合基序單鏈相互作用蛋白1，別名YC1、MSSP、SCR2、HCC-4、MSSP-1、MSSP-2、MSSP-3、C2orf12等。它是一種在人體中由RBMS1基因編碼的蛋白質(zhì)，屬于RNA結(jié)合蛋白家族成員之一。RBMS1的作用機制涉及結(jié)合單鏈DNA/RNA，具有兩個核糖核蛋白共有序列(RNP-CS)，含有保守基序RNP1和RNP2，這些基序最初在RNA結(jié)合蛋白中描述，并且對DNA結(jié)合是必需的。RBMS1參與多種生物學(xué)過程，包括DNA復(fù)制、基因轉(zhuǎn)錄、細胞周期進程和細胞凋亡 。RBMS1在生物學(xué)上的意義非常廣泛，它不僅參與了基因表達的調(diào)控，還與腫瘤免疫逃逸、細胞轉(zhuǎn)移和腫瘤抑制過程相關(guān)。例如，在三陰性乳腺癌中，RBMS1的下調(diào)能夠阻斷PD-L1免疫檢查點，促進抗腫瘤免疫 。在非小細胞肺癌中，RBMS1與m6A閱讀器YTHDF1相互作用，促進S100P的翻譯，加速癌細胞的轉(zhuǎn)移 。此外，RBMS1還通過調(diào)節(jié)SLC7A11的翻譯控制調(diào)節(jié)肺癌鐵死亡 。這些研究表明，RBMS1在腫瘤發(fā)展和轉(zhuǎn)移中發(fā)揮著重要作用，是腫瘤治療中的潛在靶點。
熱銷產(chǎn)品
RBMS1 Antibody (CSB-PA019440LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate
All lanes: RBMS1 antibody at 3.6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45, 5 kDa
Observed band size: 45 kDa
Immunofluorescence staining of HepG2 cells with CSB-PA019440LA01HU at 1:120, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
RBMS1 Antibodies
RBMS1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA019440GA01HU | RBMS1 Antibody | Human,Mouse,Rat | ELISA,IF |
| CSB-PA145037 | RBMS1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA265034 | RBMS1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA019440LA01HU | RBMS1 Antibody | Human | ELISA, WB, IF |
| CSB-PA019440LB01HU | RBMS1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA019440LC01HU | RBMS1 Antibody, FITC conjugated | Human | |
| CSB-PA019440LD01HU | RBMS1 Antibody, Biotin conjugated | Human | ELISA |
RBMS1 Proteins
RBMS1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019440HU CSB-EP019440HU CSB-BP019440HU CSB-MP019440HU CSB-EP019440HU-B |
Recombinant Human RNA-binding motif, single-stranded-interacting protein 1 (RBMS1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
