RBCK1
RanBP-type and C3HC4-type zinc finger-containing protein 1 is a protein in humans that is encoded by RBCK1 gene. E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex.
RBCK1 Antibodies
RBCK1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA880138LA01HU | RBCK1 Antibody | Human | ELISA, IHC |
| CSB-PA880138LB01HU | RBCK1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA880138LC01HU | RBCK1 Antibody, FITC conjugated | Human | |
| CSB-PA880138LD01HU | RBCK1 Antibody, Biotin conjugated | Human | ELISA |
RBCK1 Proteins
RBCK1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP019395DIL CSB-EP019395DIL CSB-BP019395DIL CSB-MP019395DIL CSB-EP019395DIL-B |
Recombinant Danio rerio RanBP-type and C3HC4-type zinc finger-containing protein 1 (rbck1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RBCK1 Proteins for Dicentrarchus labrax (European seabass) (Morone labrax)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP019395DKC CSB-EP019395DKC CSB-BP019395DKC CSB-MP019395DKC CSB-EP019395DKC-B |
Recombinant Dicentrarchus labrax RanBP-type and C3HC4-type zinc finger-containing protein 1 (rbck1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RBCK1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP720325RA CSB-BP720325RA CSB-MP720325RA CSB-EP720325RA-B |
Recombinant Rat RanBP-type and C3HC4-type zinc finger-containing protein 1 (Rbck1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RBCK1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP880138HU CSB-EP880138HU CSB-BP880138HU CSB-MP880138HU CSB-EP880138HU-B |
Recombinant Human RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RBCK1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP896241MO CSB-EP896241MO CSB-BP896241MO CSB-MP896241MO CSB-EP896241MO-B |
Recombinant Mouse RanBP-type and C3HC4-type zinc finger-containing protein 1 (Rbck1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
