RAMP2
RAMP2，全名為受體活性修飾蛋白2，常見別名為Calcitonin-receptor-like receptor activity-modifying protein 2或CRLR activity-modifying protein 2。該蛋白主要與CGRP受體（降鈣素基因相關(guān)肽受體）結(jié)合，形成異源二聚體，參與多種生理功能。RAMP2在神經(jīng)系統(tǒng)中發(fā)揮重要作用，與偏頭痛、青光眼等疾病密切相關(guān)。研究表明，RAMP2的表達(dá)異常可能與高氧肺損傷有關(guān)，其調(diào)控機(jī)制有助于理解疾病的發(fā)生發(fā)展。在藥物研發(fā)方面，針對(duì)RAMP2的拮抗劑和激動(dòng)劑已被開發(fā)用于治療偏頭痛和降糖減重等疾病。例如，Vazegepant是一種口服有效的CGRP受體拮抗劑，通過抑制RAMP2與CGRP受體的結(jié)合，緩解偏頭痛癥狀。此外，RAMP2基因敲除細(xì)胞株為藥物研發(fā)提供了重要工具，有助于探索新型治療策略。未來，RAMP2相關(guān)藥物的研發(fā)有望為相關(guān)疾病的治療帶來更多突破。
熱銷產(chǎn)品
RAMP2 Antibody (CSB-PA019305LA01HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-PA019305LA01HU diluted at 1:500 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of A549 cells with CSB-PA019305LA01HU at 1:230, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
RAMP2 Antibodies
RAMP2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA019305GA01HU | RAMP2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA827979 | RAMP2 Antibody | Human | ELISA,WB |
| CSB-PA019305LA01HU | RAMP2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA019305LC01HU | RAMP2 Antibody, FITC conjugated | Human | |
| CSB-PA019305LD01HU | RAMP2 Antibody, Biotin conjugated | Human | ELISA |
RAMP2 Proteins
RAMP2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019305HU1 CSB-EP019305HU1 CSB-BP019305HU1 CSB-MP019305HU1 CSB-EP019305HU1-B |
Recombinant Human Receptor activity-modifying protein 2 (RAMP2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF019305HU | Recombinant Human Receptor activity-modifying protein 2 (RAMP2) | in vitro E.coli expression system |
RAMP2 Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP848128GU CSB-EP848128GU CSB-BP848128GU CSB-MP848128GU CSB-EP848128GU-B |
Recombinant Guinea pig Receptor activity-modifying protein 2 (RAMP2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RAMP2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP862354RA CSB-EP862354RA CSB-BP862354RA CSB-MP862354RA CSB-EP862354RA-B |
Recombinant Rat Receptor activity-modifying protein 2 (Ramp2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RAMP2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP892990MO CSB-EP892990MO CSB-BP892990MO CSB-MP892990MO CSB-EP892990MO-B |
Recombinant Mouse Receptor activity-modifying protein 2 (Ramp2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
